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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given (comparable to standards)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1988
Reference Type:
review article or handbook
Title:
IUCLID Dataset 4-Isopropylaniline
Author:
ECB
Year:
2000
Bibliographic source:
European Chemical Bureau(ECB) European Commission
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not applicable
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-isopropylaniline
EC Number:
202-797-2
EC Name:
4-isopropylaniline
Cas Number:
99-88-7
Molecular formula:
C9H13N
IUPAC Name:
4-isopropylaniline

Test animals

Species:
rat
Sex:
male/female

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
1 030 mg/kg bw
Remarks on result:
other: rat
Sex:
male
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Remarks on result:
other: rat

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
Mean value LD50 = 1015 mg/kg bw (used for classification)
Risk of cutaneous absorption. Risk of methaemoglobin formation even after skin contact (leads to increased classification).
Symptoms may be delayed.
Executive summary:

As mention in chapter toxicikinetics read across to p-isopropyl aniline is appropriate and justified by ECB 2000 (peer reviewed data collection). p-Isopropyl aniline was applied to the skin of male and female rats as described by OECD TG 402 under GLP conditions to determine acute dermal toxicity.

The LD50 for males is 1000 mg/kg bw and for females 1030 mg/kg bw (Hoechst AG 1988)

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