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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Experiments were conducted by trusted and reliable laboratory.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Limit test)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
405-370-0
EC Name:
-
Cas Number:
6334-25-4
Molecular formula:
C14H28N2O6
IUPAC Name:
N,N,N',N'-tetrakis(2-hydroxyethyl)hexanediamide
Test material form:
solid: particulate/powder

Test animals

Species:
other: Rabbit ( New Zealand White )

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Substance ground and moistened with 0.85% saline

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; number of animals:6; Number of death:0
Female: 5000 mg/kg bw; Number of animals: 6; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: No deaths and no sign of systemic toxicity were observed. Erythema was observed on day 1, but was not scored. (Body weight loss of 5-25% was seen in 2 animals during the first week; this was attributed to stress p
Gross pathology:
Effects on organs:
No treatment-related macroscopic findings were observed in internal organs.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

Data for this end point was supplied by ECHA under SNIF#001 -4.1.30 -01