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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: SNIF file in pdf format received from ECHA

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Method

Species / strain
Species / strain / cell type:
bacteria, other: Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538
Metabolic activation:
not specified
Metabolic activation system:
Aroclor-induced rat liver s)
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation):0...5000 µg/plate
Concentration range in the main test (without metabolic activation):0...5000 µg/plate
Vehicle / solvent:
Solvetn: Water

Results and discussion

Test resultsopen allclose all
Species / strain:
other: as specified above
Metabolic activation:
with
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
> 5000 µg/plate
Species / strain:
other: as specified above
Metabolic activation:
without
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
> 5000 µg/plate
Species / strain:
other: as specified above
Metabolic activation:
with
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
> 5000 u/g/plate
Species / strain:
other: as specified above
Metabolic activation:
without
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
> 5000 u/g/plate
Additional information on results:
Observations:
No toxicity was observed
Remarks on result:
other: other: preliminary test
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

We are not in the position to fill all the fields. The data supplied as annex to ECHA Letter dated April 28, 2011 does not show other data than the one inserted here. ECHA letter "Communication relating to your inquiry under regulation (EC) no 1907/2006" ( Submission number WZ219074-00)

Applicant's summary and conclusion

Conclusions:
negative with metabolic activation
negative without metabolic activation
Executive summary:

Note: All info and data in this end point / section is according to ECHA data as annex of inquiry no 06 -0000021150 -88 -0000