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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 24 January 2011 to 25 February 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
see § Overall remarks
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
18.6 g/L
Temp.:
20 °C
pH:
2
Water solubility:
412 mg/L
Temp.:
20 °C
pH:
7
Water solubility:
475 mg/L
Temp.:
20 °C
pH:
9
Details on results:
The measurement of the solubility in water was difficult to achieve.
When using convenient buffer solutions, the measure was suspected to be biased because of the capture of Calcium in the benefit of the solubility of
tartric acid.
The experiments were done without any buffer, and the pH value of the water phase was adjusted with HCl or NaOH, as required.
The hydrosolubility at pH 2 was high, corresponding to 18.9 g/L. The hypothesis was that the solubility of tartric acid was favoured because of the
formation of CaCl2 when adding HCl for high acidification. This might be responsible for that the pH value was difficult to maintain and required
successive addition of HCl during the test period.

The pH of water for the measurement at pH 7 and pH 9 was adjusted with NaOH, and no acidification was required.
Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L) at neutral pH
Executive summary:

Water solubility of Calcium tartrate was determined according to OECD Guideline 105.

The water solubility was pH-dependent but always important:

At pH = 2, Hydrosolubility = 18.6 g/L

At pH = 7, Hydrosolubility = 412 mg/L

At pH = 9, Hydrosolubility = 475 mg/L

Description of key information

Water solubility of Calcium tartrate was determined according to OECD Guideline 105.

The water solubility was pH-dependent but always important:

At pH = 2, Hydrosolubility = 18.6 g/L

At pH = 7, Hydrosolubility = 412 mg/L

At pH = 9, Hydrosolubility = 475 mg/L

Key value for chemical safety assessment

Water solubility:
412 mg/L
at the temperature of:
20 °C

Additional information