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EC number: 221-621-5 | CAS number: 3164-34-9
Toxicological information
Repeated dose toxicity: other routes
Currently viewing:
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: 1 week
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- TARTRATE NEPHRITIS, WITH ESPECIAL REFERENCE TO SOME OF THE CONDITIONS UNDER WHICH IT MAY BE PRODUCED.
- Author:
- Underhill et al.
- Year:
- 1 913
- Bibliographic source:
- J Exp Med. 1913;18(4):322-46
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
Test material
- Reference substance name:
- sodium tartarte
- IUPAC Name:
- sodium tartarte
- Test material form:
- not specified
- Details on test material:
- No details on test material identity are available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Male Rabbit, Weighing 2,200 Grams
Female Rabbit, Weighing 2,200 Grams
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Details on exposure:
- Subcutaneous injection of tartaric acid neutralized with sodium carbonate in water without phlorizin administration
- Duration of treatment / exposure:
- 1 week
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
RABBIT E: subcutaneous injection of 3 gm tartaric acid, neutralized with sodium carbonate, in 40 c.c. water.
RABBIT F: subcutaneous injection of 3 gm tartaric acid neutralized with sodium carbonate.
- No. of animals per sex per dose:
- 1 male and 1 female
- Control animals:
- not specified
- Details on study design:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- one animal found dead.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- one animal found dead.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- effects observed, treatment-related
- Description (incidence and severity):
- determination of creatinin and total nitrogen
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Kidneys were pale and soft.
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- RABBIT E - Histological Examination. Kidney. Necrosis of the convoluted tubules is almost universal, and the necrotic epithelium is generally disintegrated. The collecting tubules show little change and there are many casts. The glomerules and interstitial tissue seem unaffected. Determination of creatinin and total nitrogen.
RABBIT F - Histological Examination. Kidney.Necrosis of the convoluted tubules is almost universal, and the necrotic epithelium is generally disintegrated. The collecting tubules show little change and there are many casts. The glomerules and interstitial tissue seem unaffected.In the pelvis is a mass of coagulated protein, apparently from highly albuminous urine. Determination of creatinin and total nitrogen.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 3 other: gm
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Found dead.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 3 other: gm
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Animal in light coma. Kidneys were pale and soft.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Significant toxic effect occurred in rabbit after daily subcutaneous injection of tartaric acid, neutralized with sodium carbonate. The kidney is main organ involved.
- Executive summary:
The subcutaneous administration of sodium tartrate to rabbit caused a pronounced disintegrative action upon the epithelium of the kidney.
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