Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-621-5 | CAS number: 3164-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: 1 week
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- TARTRATE NEPHRITIS, WITH ESPECIAL REFERENCE TO SOME OF THE CONDITIONS UNDER WHICH IT MAY BE PRODUCED.
- Author:
- Underhill et al.
- Year:
- 1 913
- Bibliographic source:
- J Exp Med. 1913;18(4):322-46
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
Test material
- Reference substance name:
- sodium tartarte
- IUPAC Name:
- sodium tartarte
- Test material form:
- not specified
- Details on test material:
- No details on test material identity are available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Male Rabbit, Weighing 2,200 Grams
Female Rabbit, Weighing 2,200 Grams
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- water
- Details on exposure:
- Subcutaneous injection of tartaric acid neutralized with sodium carbonate in water without phlorizin administration
- Duration of treatment / exposure:
- 1 week
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
RABBIT E: subcutaneous injection of 3 gm tartaric acid, neutralized with sodium carbonate, in 40 c.c. water.
RABBIT F: subcutaneous injection of 3 gm tartaric acid neutralized with sodium carbonate.
- No. of animals per sex per dose:
- 1 male and 1 female
- Control animals:
- not specified
- Details on study design:
- no data
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- one animal found dead.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- one animal found dead.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- effects observed, treatment-related
- Description (incidence and severity):
- determination of creatinin and total nitrogen
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Kidneys were pale and soft.
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- RABBIT E - Histological Examination. Kidney. Necrosis of the convoluted tubules is almost universal, and the necrotic epithelium is generally disintegrated. The collecting tubules show little change and there are many casts. The glomerules and interstitial tissue seem unaffected. Determination of creatinin and total nitrogen.
RABBIT F - Histological Examination. Kidney.Necrosis of the convoluted tubules is almost universal, and the necrotic epithelium is generally disintegrated. The collecting tubules show little change and there are many casts. The glomerules and interstitial tissue seem unaffected.In the pelvis is a mass of coagulated protein, apparently from highly albuminous urine. Determination of creatinin and total nitrogen.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 3 other: gm
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Found dead.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 3 other: gm
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Animal in light coma. Kidneys were pale and soft.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Conclusions:
- Significant toxic effect occurred in rabbit after daily subcutaneous injection of tartaric acid, neutralized with sodium carbonate. The kidney is main organ involved.
- Executive summary:
The subcutaneous administration of sodium tartrate to rabbit caused a pronounced disintegrative action upon the epithelium of the kidney.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.