2-bromoethylammonium bromide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Data is from per- reviewed journal

Data source

Reference

Reference Type:

publication

Title:

Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice

Author:

E. W. Schafer, Jr. and W. A. Bowles, Jr.

Year:

1985

Bibliographic source:

Archives of Environmental Contamination and Toxicology; 14, 111-129 (1985)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity and repellency study of 2-bromoethanaminium bromide in mice

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-bromoethylammonium bromide

EC Number:

219-924-2

EC Name:

2-bromoethylammonium bromide

Cas Number:

2576-47-8

Molecular formula:

C2H6BrN.BrH

IUPAC Name:

2-bromoethanaminium bromide

Test material form:

solid

Details on test material:

- Name of test material (as cited in study report):2-Bromoethylamine hydrobromide
- Molecular formula :C2H6BrNBrH
- Molecular weight: 204.892 g/mol
- Substance type:Organic
- Physical state:Solid

Specific details on test material used for the study:

- Name of test material (as cited in study report): 2-bromoethanaminium bromide
- Molecular formula (if other than submission substance): C2H6BrN.BrH
- Molecular weight (if other than submission substance): 204.892 g/mole
- Substance type: Organic
- Physical state: Solid

Test animals

Species:

mouse

Strain:

other: Deer

Sex:

not specified

Details on test animals or test system and environmental conditions:

- Weight at study initiation: 20 gms
- Diet (e.g. ad libitum): wheat seed

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: Water , corn oil, 1% carbopol

Details on oral exposure:

2-bromoethanaminium bromide was administrated by gavage using Water , corn oil, 1% carbopol as carriers.

Doses:

1138 mg/kg bw

No. of animals per sex per dose:

2 to 4 animals were used per geometrically spaced dosage.

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 3 days

Statistics:

estimated by method of thompson and weil

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 1 138 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality observed

Mortality:

No mortality was observed in treated mice at 1138 mg/kg

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 was considered to be > 1138 mg/kg bw when Deer mice were treated with 2-bromoethanaminium bromide orally by gavage.

Executive summary:

In a acute oral toxicity study, Deer mice were treated with 2-bromoethanaminium bromide in the concentration of 1138 mg/kg bw orally by gavage using Water , corn oil, 1% carbopol as carriers and observed for 3 days. No 50 % mortality was observed in treated mice at 1138 mg/kg bw. Therefore, LD50 was considered to be > 1138 mg/kg bw when Deer mice were treated with 2-bromoethanaminium bromide orally by gavage.