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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Data is from per- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute Oral Toxicity and Repellency of 933 Chemicals to House and Deer Mice
Author:
E. W. Schafer, Jr. and W. A. Bowles, Jr.
Year:
1985
Bibliographic source:
Archives of Environmental Contamination and Toxicology; 14, 111-129 (1985)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity and repellency study of 2-bromoethanaminium bromide in mice
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-bromoethylammonium bromide
EC Number:
219-924-2
EC Name:
2-bromoethylammonium bromide
Cas Number:
2576-47-8
Molecular formula:
C2H6BrN.BrH
IUPAC Name:
2-bromoethanaminium bromide
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report):2-Bromoethylamine hydrobromide
- Molecular formula :C2H6BrNBrH
- Molecular weight: 204.892 g/mol
- Substance type:Organic
- Physical state:Solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-bromoethanaminium bromide
- Molecular formula (if other than submission substance): C2H6BrN.BrH
- Molecular weight (if other than submission substance): 204.892 g/mole
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
other: Deer
Sex:
not specified
Details on test animals or test system and environmental conditions:
- Weight at study initiation: 20 gms
- Diet (e.g. ad libitum): wheat seed

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Water , corn oil, 1% carbopol
Details on oral exposure:
2-bromoethanaminium bromide was administrated by gavage using Water , corn oil, 1% carbopol as carriers.
Doses:
1138 mg/kg bw
No. of animals per sex per dose:
2 to 4 animals were used per geometrically spaced dosage.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 3 days
Statistics:
estimated by method of thompson and weil

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 138 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated mice at 1138 mg/kg
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be > 1138 mg/kg bw when Deer mice were treated with 2-bromoethanaminium bromide orally by gavage.
Executive summary:

In a acute oral toxicity study, Deer mice were treated with 2-bromoethanaminium bromide in the concentration of 1138 mg/kg bw orally by gavage using Water , corn oil, 1% carbopol as carriers and observed for 3 days. No 50 % mortality was observed in treated mice at 1138 mg/kg bw. Therefore, LD50 was considered to be > 1138 mg/kg bw when Deer mice were treated with 2-bromoethanaminium bromide orally by gavage.