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EC number: 219-924-2 | CAS number: 2576-47-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- gene mutation study in yeast
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Testing of chemicals for mutagenic activity with Schizosaccharomyces pombe- A report of the U.S. Environmental Protection Agency Gene-Tox Program
- Author:
- N. Loprieno, R. Barale , E.S. Von Halle and R.C. yon Borstel
- Year:
- 1 983
- Bibliographic source:
- Mutation Research, 115 (1983) 215-223
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Reverse mutation was studied for the 2-Bromoethaneamine hydrobromide using yeast Schizosaccharomyces pombe
- GLP compliance:
- not specified
- Type of assay:
- other: Schizosaccharomyces pombe gene mutation assay
Test material
- Reference substance name:
- 2-bromoethylammonium bromide
- EC Number:
- 219-924-2
- EC Name:
- 2-bromoethylammonium bromide
- Cas Number:
- 2576-47-8
- Molecular formula:
- C2H6BrN.BrH
- IUPAC Name:
- 2-bromoethanaminium bromide
- Test material form:
- solid
- Details on test material:
- SMILES:BrCCN{+}.Br{-}
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2-Bromoethaneamine hydrobromide
- Molecular formula: C2H6BrNBrH
- Molecular weight: 204.892 g/mol
- Substance type: Organic
- Physical state: No data
- Purity: No data
- Impurities (identity and concentrations): No data
Method
- Target gene:
- his52, his7, met4, ade6 and ade7
Species / strain
- Species / strain / cell type:
- yeast, other: Schizosaccharomyces pombe strain Arg 1
- Details on mammalian cell type (if applicable):
- Not applicable
- Additional strain / cell type characteristics:
- not specified
- Cytokinesis block (if used):
- No data
- Metabolic activation:
- without
- Metabolic activation system:
- Exogeneous metabolic activation system- S9 and S100
- Test concentrations with justification for top dose:
- No data
- Vehicle / solvent:
- No data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- No data
- Rationale for test conditions:
- No data
- Evaluation criteria:
- The yeast cells were observed for reversion of mutation
- Statistics:
- No data
Results and discussion
Test results
- Species / strain:
- yeast, other: Schizosaccharomyces pombe strain Arg 1
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- No data
Any other information on results incl. tables
Table: Chemicals Tested for Mutagenicity on Stationary Phase Cells of Schizosaccharomyces pombe
Chemical |
Strain |
Metabolic activation |
Genetic end point |
Genetic activity |
2-Bromoethaneamine hydrobromide |
Arg 1 |
- |
Reverse mutation |
+ |
Applicant's summary and conclusion
- Conclusions:
- 2-Bromoethaneamine hydrobromide induced reversion of mutation in yeast Schizosaccharomyces pombe and hence the chemical is likely to be mutagenic to yeast cells.
- Executive summary:
Reverse mutation was studied for the 2-Bromoethaneamine hydrobromide using yeast Schizosaccharomyces pombe strain Arg 1. The study was performed without exogeneous metabolic activation system at either of the his52, his7, met4, ade6 and ade7 locus. All these systems allow the evaluation of back mutation induction at the original mutant site. 2-Bromoethaneamine hydrobromide induced reversion of mutation in yeast Schizosaccharomyces pombe without exogeneous metabolic activation system and hence the chemical is likely to be mutagenic to yeast cells.
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