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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1948
Reference Type:
publication
Title:
Range-finding toxicity data: list III.
Author:
Smyth, H.F. et al.
Year:
1949
Bibliographic source:
J. Ind. Hyg. Toxicol. 31, 60-62

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
see details in remarks on material and methods.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexylamine
EC Number:
203-233-8
EC Name:
2-ethylhexylamine
Cas Number:
104-75-6
Molecular formula:
C8H19N
IUPAC Name:
2-ethylhexylamine

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
open
Preparation of test site:
clipped
Vehicle:
other: acetone
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.01 mL
- Concentration: undiluted or as 10% dilution in acetone

Duration of treatment / exposure:
4 h or 24 h
Observation period:
24 h
Number of animals:
5

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
6
Max. score:
10
Reversibility:
no data

Any other information on results incl. tables

In a vesicant test the undiluted compound produced necrosis on 4 of 5 rabbits, but irritation was practically nil with a 10% dilution in acetone. A 4 h rabbit belly irritation test also indicated the production of necroses of the skin.

Applicant's summary and conclusion