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EC number: 701-197-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Patty´s Industrial Hygiene and Toxicology
- Author:
- Hine, Rowe, White, Darmer, Jr. and Youngblood
- Year:
- 1 981
- Bibliographic source:
- 3rd ED. 1981 Vol II A, page 2237- 2240
Materials and methods
- Principles of method if other than guideline:
- The information does not come from a test report and the minimum fields can not be filled in.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Polyglycidyl ether of substituted glycerine (EPON 562)
- IUPAC Name:
- Polyglycidyl ether of substituted glycerine (EPON 562)
- Details on test material:
- - Name of test material (as cited in study report): Polyglycidyl ether of substituted glycerine (EPON 562)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intramuscular
- Frequency of treatment:
- 6 doses
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 and 0.2 g/kg
Results and discussion
Results of examinations
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No information is available concerning methods used, guidelines followed. However, as the data comes from a peer-reviewed handbook, the information is considered to be of high quality (reliability Klimisch 2). The test material did not induce any effects at 0.1 g/kg but at 0.2 g/kg depression of white cell count and bone marroy nucleated cell count were noted after application of the test substance to rats at 0.1 and 0.2 g/kg intramuscularly for 6 applications.
- Executive summary:
The Patty´s Industrial Hygiene and Toxicology also contains information about 1,2,3 -propanetriol, glycidyl ethers (Patty's Industrial Hygiene and Toxicology, 3erd Ed, Hine et al., 1981). There a study is mentioned, where the test substance was administered intramuscular to rats at 0.1 and 0.2 g/kg for 6 applications. No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count.
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