Reaction products of 2-(chloromethyl)oxirane and glycerol

Repeated dose toxicity: other routes

Administrative data

Endpoint:

repeated dose toxicity: other route

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: peer-reviewed handbook

Data source

Reference

Reference Type:

review article or handbook

Title:

Patty´s Industrial Hygiene and Toxicology

Author:

Hine, Rowe, White, Darmer, Jr. and Youngblood

Year:

1981

Bibliographic source:

3rd ED. 1981 Vol II A, page 2237- 2240

Materials and methods

Principles of method if other than guideline:

The information does not come from a test report and the minimum fields can not be filled in.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Polyglycidyl ether of substituted glycerine (EPON 562)

IUPAC Name:

Polyglycidyl ether of substituted glycerine (EPON 562)

Details on test material:

- Name of test material (as cited in study report): Polyglycidyl ether of substituted glycerine (EPON 562)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

intramuscular

Frequency of treatment:

6 doses

Doses / concentrations

Remarks:

Doses / Concentrations:
0.1 and 0.2 g/kg

Results and discussion

Results of examinations

Haematological findings:

effects observed, treatment-related

Description (incidence and severity):

No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

No information is available concerning methods used, guidelines followed. However, as the data comes from a peer-reviewed handbook, the information is considered to be of high quality (reliability Klimisch 2). The test material did not induce any effects at 0.1 g/kg but at 0.2 g/kg depression of white cell count and bone marroy nucleated cell count were noted after application of the test substance to rats at 0.1 and 0.2 g/kg intramuscularly for 6 applications.

Executive summary:

The Patty´s Industrial Hygiene and Toxicology also contains information about 1,2,3 -propanetriol, glycidyl ethers (Patty's Industrial Hygiene and Toxicology, 3erd Ed, Hine et al., 1981). There a study is mentioned, where the test substance was administered intramuscular to rats at 0.1 and 0.2 g/kg for 6 applications. No effects at 0.1 g/kg, At 0.2 g/kg depresion of white cell count and bone marrow nucleated cell count.