Registration Dossier
Registration Dossier
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EC number: 203-120-3 | CAS number: 103-53-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- No information on test method available.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Phenethyl cinnamate
- EC Number:
- 203-120-3
- EC Name:
- Phenethyl cinnamate
- Cas Number:
- 103-53-7
- Molecular formula:
- C17H16O2
- IUPAC Name:
- phenethyl cinnamate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Mortality:
- 0/10
- Clinical signs:
- Diarrhea in 2 animals out of 10 on day 1.
Slight redness in 2 out of 10 animals; slight edema in 1 out of 10.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008
- Conclusions:
- The test item tested via dermal route had an LD50 greater than 5000 mg/kg bw
- Executive summary:
In the current test the acute toxicity via the dermal route of the test item was assessed in rabbits. A single dose of 5000 mg/kg bw of the test substance was applied to 10 animals. No animals died and therefore the LD50 > 5000 mg/kg bw. Slight erythema was observed in 2/10 animals, slight edema in 1/10. Furthermore, 2 rabbits had diarrhea on day 1.
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