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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The study was conducted on15 March 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
not specified
GLP compliance:
not specified
Remarks:
Study was not conducted under a specific Good Laboratory Practices (GLP) program, this study was conducted following the principles of GLP by experienced and trained personnel using calibrated standards and instrumentation. Relevant SOPs were followed.
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Lot/Batch number: 1004R18708
Key result
Type:
log Pow
Partition coefficient:
> 1 - < 1.5
Temp.:
20 °C
pH:
> 6.2 - < 6.5
Details on results:
The mean log Pow for RD14156 is 1.2.

Mass balance and octanol/water ratio for RD14156.

 Run #  RD 14156 added  RD 14156 dissolved  Ratio octanol/water  Log octanol/water
 1A  0.507  0.217  15.7  1.2
 1B  0.503  0.235  22.3  1.3
 2A  0.504  0.249  9.61  1.0
 2B  0.504  0.245  10.9  1.0
 3A  0.533  0.250  29.2  1.5
 3C  0.509  0.216  25.6  1.4
 Mean      18.9  1.24
 Std Devn.      8.05  0.20
Conclusions:
The mean log Pow of RD14156, over six determinations, is 1.2.
Executive summary:

The RD14156 material under test was analyzed per guidelines as set forth in OECD 107, partition coefficient, shake flask method. The mean log Pow for RD14156 is 1.2.

Description of key information

The RD14156 material under test was analyzed per guidelines as set forth in OECD 107, partition coefficient, shake flask method. The mean log Pow for RD14153 is 1.2.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.2

Additional information