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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 24 March 2016 and 09 April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other:
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Sponsor Lot/Batch number 5399561P10
- Expiration date of the lot/batch: 25 January 2020
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
- Preliminary purification step (if any):
- Final dilution of a dissolved solid, stock liquid or gel:
- Final preparation of a solid:
FORM AS APPLIED IN THE TEST (if different from that of starting material)
OTHER SPECIFICS: - Radiolabelling:
- no
- Details on study design: HPLC method:
- Determination of retention time
The sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System : Agilent Technologies 1200 series
Column : Waters XSelect HSS Cyano 5 mm (150 x 4.6 mm id)
Column temperature : 30 ºC
Mobile phase : Methanol: purified water (55:45 v/v)
100% methanol post 30 minutes for samples
pH of mobile phase : 6.9
Flow-rate : 1.0 mL/min
Injection volume : 10 μL standards, 25 mL samples
UV detector wavelength : 210 nm - Key result
- Type:
- log Koc
- Value:
- > 1.25 - < 5.63
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: See Table 2
- Details of fitted regression line (log k' vs. log Koc): Y = 0.3355x - 0.7268
- Graph of regression line attached: no
- Average retention data for test substance: 17.9 mins - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to have a range of <17.8 to > 4.27 x 105, log10 Koc <1.25 to >5.63, with the largest peak by area percent being represented by an adsorption coefficient 7.43 x 10,000, log10 Koc 4.87.
- Executive summary:
The adsorption coefficient (Koc) of the test item has been determined to have a range of <17.8 to >4.27 x 105, log10Koc <1.25 to>5.63, with the largest peak by area being represented by an adsorpton coefficient of 7.43 x 104, log10 Koc4.87, using the HPLC screening method, designed to be compatible with Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001 Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Reference
Table 2: Retention times, capacity factors and log10Kocvalues for reference standards.
Standard | Mean retention time (mins) | Capacity factor (k') | Log10k' | Log10Koc |
Acetanilide | 2.689 | 0.365 |
-0.438 |
1.25 |
Phenol |
2.551 |
0.296 |
-0.530 |
1.32 |
Atrazine |
3.713 |
0.885 |
-5.31 x 10-2 |
1.81 |
Isoproturon |
3.962 |
1.011 |
4.79 x 10-3 |
1.86 |
Triadimenol |
5.278 |
1.679 |
0.225 |
2.40 |
Linuron |
5.404 |
1.743 |
0.214 |
2.59 |
Naphthalene |
4.677 |
1.374 |
0.138 |
2.75 |
Endosulfan-diol |
6.613 |
2.357 |
0.372 |
3.02 |
Fenthion |
7.997 |
3.060 |
0.486 |
3.31 |
alpha-Endosulfan |
11.167 |
4.669 |
0.669 |
4.09 |
Diclofop-methyl |
12.078 |
5.131 |
0.710 |
4.20 |
Phenanthrene |
8.658 |
3.395 |
0.831 |
4.09 |
DDT |
24.083 |
11.225 |
1.05 |
5.63 |
Table 3: Retention times, capacity factor, log10and Kocvalues for RD14156
Peak |
Mean retention time (mins) |
Mean capacity factor (k') |
Mean Log10Koc |
Adsorption coeff. |
Mean % area |
1 |
2.026 |
2.83 x 10-2 |
<1.25 |
<17.8 |
34.8 |
2 |
17.876 |
8.08 |
4.87 |
7.43 x 104 |
56.5 |
3 |
39.090 |
18.8 |
>5.63 |
<4.27 x 105 |
5.82 |
4 | 40.465 | 19.5 | >5.63 | <4.27 x 105 |
0.218 |
5 | 40.842 | 19.7 | >5.63 | <4.27 x 105 |
0.156 |
6 | 41.606 | 20.1 | >5.63 | <4.27 x 105 |
0.522 |
7 | 42.344 | 20.5 | >5.63 | <4.27 x 105 |
0.294 |
8 | 42.799 | 20.7 | >5.63 | <4.27 x 105 |
1.16 |
9 | 11.010 | 21.3 | >5.63 | <4.27 x 105 |
0.563 |
Summary of log10 Koc: <1.25 to >5.63
Adsorptioin coefficient: <17.8 to >4.27 x 105
Description of key information
The adsorption coefficient (Koc) of the test item has been determined to have a range of <17.8 to >4.27 x 105, log10Koc<1.25 to>5.63, with the largest peak by area being represented by an adsorpton coefficient of 7.43 x 104, log10Koc4.87, using the HPLC screening method.
Key value for chemical safety assessment
- Koc at 20 °C:
- 74 131
Additional information
[LogKoc: 4.87]
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