(chloromethyl)vinylbenzene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1955

Report date:

1955

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Not specified

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

(chloromethyl)vinylbenzene

EC Number:

250-005-9

EC Name:

(chloromethyl)vinylbenzene

Cas Number:

30030-25-2

Molecular formula:

C9H9Cl

IUPAC Name:

1-(chloromethyl)-3-ethenylbenzene; 1-(chloromethyl)-4-ethenylbenzene

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

not specified

Dose descriptor:

LD100

Effect level:

1 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

not specified

Dose descriptor:

LD0

Effect level:

500 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

Material	Condition of skin	No. of Application	Site	Response - Remarks
100%	Intact	1	Ear	Slight reddening of the skin, a trace of edema, and slight necrosis developing to scab and scar formation.
100%	Intact	1	Belly	Moderate reddening of the skin, trace of edema, moderate necrosis developing to scab and scar formation.
100%	Abraded	1	Belly	Moderate reddening of the skin, trace of edema, moderate necrosis developing to heavy scab and scar formation.
10 % in Dowanol 50 B	Intact	10	Ear	No response developing to a slight reddening of the skin and slight necrosis after 6 or 7 applications.
11 % in Dowanol 50 B	Intact	4	Belly	Essentially no response developing to moderate reddening of the skin and slight necrosis after 4 applications.
12 % in Dowanol 50 B	Abrades	3	Belly	Essentially no response developing to marked edema and necrosis after 3 applications with development of heavy scab and scar formation

Skin contact - Absorption (24 hours Exposure)

Animal	Preparation used	Dose (g/kg)	No. died / No. Treated	Response - Remarks
Rabbit	10 % in propylene glycol	0.5	0/2	No apparent effect other than extensive scab and scar formation
Rabbit	10 % in propylene glycol	1.0	2/2	Death occurred in 1 day

Applicant's summary and conclusion

Interpretation of results:

other: Category 3 based on EU GHS

Conclusions:

The undiluted test material vinylbenzyl chloride has a severe effect on intact and abraded skin. Repeated, prolonged contact, over a period of 1 to 2 days is capable of causing marked to severe damage.
This material is markedly irritating and damaging to skin on prolonged or repeated contact. It has a moderate acute toxicity by skin absorption.

Executive summary:

The undiluted test material vinylbenzyl chloride has a severe effect on intact and abraded skin. Repeated, prolonged contact, over a period of 1 to 2 days is capable of causing marked to severe damage.

This material was found to be markedly irritating and damaging to skin on prolonged or repeated contact. It had a moderate acute toxicity by skin absorption. After 24 hours skin contact / absorption at a dose of 0.5 g/kg bw (10% solution in propylene glycol), no death and no apparent effect other than extensive scab and scar formation was noted in 2 out of 2 exposed animals. At a dose level of 1 g/kg bw 2 test animals died within 1 day. Based on these these observations, vinylbenzyl chloride was classified in Cat. 3 of acute dermal toxicity.