Registration Dossier
Registration Dossier
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EC number: 241-165-0 | CAS number: 17096-07-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Bacterial mutagenicity: negative with and without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or E. coli WP2 uvrA (Sogo, 1987).
Cytogenicity in mammalian cells: negative with and without metabolic activation in Chinese hamster Ovary cells (CIVO, 1988).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
3-[3,3,3-Trimethyl-1,1-bis[(trimethylsilyl)oxy]disiloxanyl]propyl methacrylate has been tested for mutagenicity to bacteria, in a study which was conducted according to a test protocol that is comparable to the appropriate OECD test guideline but not compliant with GLP (Sogo, 1987).
No evidence of a test-substance related increase in the number of revertants was observed with or without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or E. coli WP2 uvrA in the initial or the repeat experiments up to limit concentrations. Appropriate positive and solvent controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
3-[3,3,3-Trimethyl-1,1-bis[(trimethylsilyl)oxy]disiloxanyl]propyl methacrylate has been tested in a valid study according to a protocol similar to OECD 473 and under GLP, up to limit concentrations (CIVO, 1988). No increase in the number of cells with aberrations was observed either with or without metabolic activation in Chinese hamster Ovary cells. Appropriate solvent and positive controls were included and gave expected results. It is concluded that the test substance is negative for the induction of chromosome aberrations under the conditions of this study.
Justification for classification or non-classification
Based on the available data, no classification is required for 3-[3,3,3-trimethyl-1,1-bis[(trimethylsilyl)oxy]disiloxanyl]propyl methacrylate for genetic toxicity according to Regulation (EC) No 1272/2008.
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