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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian germ cell study: gene mutation
Type of information:
read-across from similar mixture/product
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Reliability assessment as per that quoted in IUCLID 4 (2000) data review. Read across from supporting substance (structural analogue ot surrogate)

Data source

Reference
Title:
Chemical Induction of nondijunction in drosphilia
Author:
Ramel, C., Magnusson, J.
Year:
1979
Bibliographic source:
Environ. Health Persp. Vol 31, pp 59-66

Materials and methods

Principles of method if other than guideline:
Method: other outlined in publication
GLP compliance:
not specified
Type of assay:
Drosophila SLRL assay

Test material

Constituent 1
Reference substance name:
Triethyllead chloride
IUPAC Name:
Triethyllead chloride

Test animals

Species:
Drosophila melanogaster
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
oral: feed
Doses / concentrations
Dose / conc.:
16 mg/kg bw (total dose)

Results and discussion

Test results
Sex:
female
Genotoxicity:
ambiguous
Toxicity:
yes

Applicant's summary and conclusion

Conclusions:
Interpretation of results: ambiguous
Executive summary:
16 mg Triel / L caused interference with meiotic nuclear division (chromosone segregation) in the offspring of female larvae of Drosophila melanogaster. The sex chromosomes were particularly affected, so that gametes with two X chromosomes (XXY individuals) occurred, while the distribution of the autosomes was not affected. From this it was deduced that TriEL has an effect on the spindle mechanism in the chromosome distribution to the daughter cells