Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

The acute toxicity of 5-Amino-o-cresol on aquatic organisms was determined on the 3 trophic levels (Fish, daphnids and algae) according to OECD guidelines and following GLP :

- 96h LC50 on Zebrafish = 25 mg/L, based on nominal concentrations (tested concentrations were stable) and according to OECD 236;

- 48h EC50 on Daphnia magna = 2.3 mg/L, based on nominal concentrations (tested concentrations were stable) and according to OECD 202;

- 72h EC50 (growth rate) on Pseudokirchneriella subcapitata = 41 mg/l based on geometric mean measured concentrations and according to OECD 201. The NOEC (growth rate) = 3.3 mg/L (geometric mean measured concentrations).

The chronic toxicity of 5 -Amino-o-cresol was assessed on algae (see NOEC (growth rate) = 3.3 mg/L above) and on daphnids with the reproduction test OECD 211. The 21 day-NOEC on Daphnia magna = 0.24 mg/L based on time-weighted mean measured concentrations.

Daphnia is the most sensitive species to the substance 5 -Amino-o-cresol, and the NOEC of 0.24 mg/L is used to calculate the PNEC to the aquatic organisms.

The EC50 total respiration > 150 mg/L is considered as the most reliable value which integrate the effect of the 5 -amino-o-cresol on the functionning of all organisms in a STP. It is prefered to the NOEC which is more dependant on the choice of the tested concentrations.

Additional information