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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Description of key information

TEGME (measured) :-1.12
TEGBE (measured): 0.56
TEGEE (calculated): -0.96
TetraEGEE (calculated): -1.24

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

There is no measured value available for the partition co-efficient of this substance. There is however measured data for two similar triethylene glycol ethers that can be used as read across substances and to justify the validity of a QSAR used to predict the value for the main components of this UVCB substance. 2-(2-(2 -methoxyyethoxy)ethoxy)ethanol (TEGME) has a measured value of -1.12 for log kow whereas 2-(2-(2 -butoxyyethoxy)ethoxy)ethanol has a value of 0.51. The value for 2-(2-(2-ethoxyyethoxy)ethoxy)ethanol (TetraEGEE) will fall between these two values. The predicted values for the logkow using the Epiwin QSAR are shown below:

 Substance  Measured logKow  QSAR value
 TEGME  -1.12  -1.46
 TEGEE    -1.24
 TEGBE  0.51  0.02

The QSAR seems to underpredict by a value of about 0.35 to 0.45. The QSAR predicted values for the logKow of the two major components of this UVCB substance are -0.96 and -1.24 respectively. Assuming therefore a logKow somewhere midway and then correcting for the offset between the measured and predicted values for the substances where both values are available, would lead to an estimate for the logKow of ~-0.7. This value is taken forward as the key parameter for this end point. A justification for read across/interpolation is attached to chapter 13 of the lead registrant's dossier.