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EC number: 204-024-4 | CAS number: 113-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates โ in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic and Histologic Effects of Sodium PyruvateTreatment in the Rat after Cortical Contusion Injury
- Author:
- Masamichi Fukushima, Stefan M. Lee, Nobuhiro Moro, David A. Hovda, and Richard L. Sutton
- Year:
- 2 009
- Bibliographic source:
- JOURNAL OF NEUROTRAUMA 26:1095โ1110 (July 2009)ยช Mary Ann Liebert, Inc.
DOI: 10.1089=neu.2008.0771
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The publication provides suffient details on the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium pyruvate
- EC Number:
- 204-024-4
- EC Name:
- Sodium pyruvate
- Cas Number:
- 113-24-6
- Molecular formula:
- C3H4O3.Na
- IUPAC Name:
- sodium 2-oxopropanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- he SP (P2256, Sigma, St. Louis, MO) was dissolved in sterile water (500 mg=mL, 4.5 M, pH 7.4) immediately prior to scheduled injections.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: intraperitoneal
- Vehicle:
- water
- Details on dermal exposure:
- Animals received an injection of sodium pyruvate (500 or 1000 mr/kg bw).
- Doses:
- 500 mg/kg bw
1000 mg/kg bw
3x 1000 mg/kg bw hourly - No. of animals per sex per dose:
- at least 5 per dose
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- not observed
Applicant's summary and conclusion
- Conclusions:
- Even with three hourly intraperitoneal injections of sodium pyruvate no deaths occured.
The uptake during dermal exposure with the same amount of substance would be lower. As a worst-case assumption it can be stated that the LC50, dermal is >= 3000 mg/kg bw.
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