Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-024-4 | CAS number: 113-24-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic and Histologic Effects of Sodium PyruvateTreatment in the Rat after Cortical Contusion Injury
- Author:
- Masamichi Fukushima, Stefan M. Lee, Nobuhiro Moro, David A. Hovda, and Richard L. Sutton
- Year:
- 2 009
- Bibliographic source:
- JOURNAL OF NEUROTRAUMA 26:1095–1110 (July 2009)ª Mary Ann Liebert, Inc.
DOI: 10.1089=neu.2008.0771
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The publication provides suffient details on the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium pyruvate
- EC Number:
- 204-024-4
- EC Name:
- Sodium pyruvate
- Cas Number:
- 113-24-6
- Molecular formula:
- C3H4O3.Na
- IUPAC Name:
- sodium 2-oxopropanoate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- he SP (P2256, Sigma, St. Louis, MO) was dissolved in sterile water (500 mg=mL, 4.5 M, pH 7.4) immediately prior to scheduled injections.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: intraperitoneal
- Vehicle:
- water
- Details on dermal exposure:
- Animals received an injection of sodium pyruvate (500 or 1000 mr/kg bw).
- Doses:
- 500 mg/kg bw
1000 mg/kg bw
3x 1000 mg/kg bw hourly - No. of animals per sex per dose:
- at least 5 per dose
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Mortality:
- not observed
Applicant's summary and conclusion
- Conclusions:
- Even with three hourly intraperitoneal injections of sodium pyruvate no deaths occured.
The uptake during dermal exposure with the same amount of substance would be lower. As a worst-case assumption it can be stated that the LC50, dermal is >= 3000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
