Symclosene

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

An air comparison pycnometer was used to measure the relative density of a number of production samples of TCCA

GLP compliance:

no

Type of method:

pycnometer method

Type:

relative density

Density:

>= 1.93 - <= 2.1 other:

Temp.:

20 °C

Table 1: Experimental data

% clear ACL-85	Density in g/cc	calc % clear ACL-85
0	1.9302	1.5
20	1.9562	18.7
40	1.9861	38.6
60	2.0196	60.8
80	2.0484	79.9
100	2.0793	100.4

% clear ACL -85 =663 (density) - 1279

The reported densities were converted into relative density by dividing by the density of water at 4 °C (0.9999720 g/cc).

The relative density varied from 1.930 to 2.097 depending on the relative amounts of clear crystals (low temperature phase material which has precipitated from solution in crystalline form and has never been through the high temperature phase) and opaque crystals (low temperature phase solid which has previously been converted from high temperature phase solid). The relative density for 48 samples from a production run in February 1968 ranged from 2.056 to 2.097. Material with 100% clear crystals has the highest density (2.097) and this can be considered to be the relative density of pure low temperature phase TCCA.

Conclusions:

Relative density of symclosene ranges from 1.930 to 2.097

Reference 2

Endpoint:

density, other

Type of information:

not specified

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

The data is provided is provided in a summary table within the report. No details of methods are reported.

Principles of method if other than guideline:

The data is provided is provided in a summary table within the report. No details of methods are reported.

GLP compliance:

no

Type of method:

pycnometer method

Type:

density

Density:

>= 2.04 - <= 2.1 other: g/mL

Temp.:

25 °C

Conclusions:

The relative density of TCCA is 2.04 - 2.10 @ 25°C

Description of key information

Relative density can be considered to be  1.93 - 2.10

Key value for chemical safety assessment

Relative density at 20C:

2.1

Additional information

Three sources of information are available. Brautigam (1968) reports the relative density to be in the range of 1.930 to 2.097 using the pycnometer method.

In a study (Wo C 2007) the tap density and pour density were determined to be 1.097 g/mL and 1.034 g/mL respectively.

Nelson (1975) reports the relative density to be 2.04 - 2.10 @ 25°C