Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Link to relevant study record(s)

Description of key information

EFSA in its Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives (2014) noted that the ADME data of propionate indicated that oral exposure results in significant absorption. The EFSA Panel noted that in the gastrointestinal tract, sodium propionate, calcium propionate and potassium propionate will be dissociated into sodium ion, potassium ion or calcium ion and propionate ion. Comparable behaviour can also be expected for zinc dipropionate. Thus, zinc diporopionate liberates its moieties zinc and propionate under physiological relevant conditions. For toxicokinetic, metabolism and excretion of these moieties please refer to the respective assessment entities.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information