Registration Dossier
Registration Dossier
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EC number: 209-167-6 | CAS number: 557-28-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propionic acid
- Details on test material:
- - Name of test material (as cited in study report): Propionsäure Hoe 31891
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, Pharma Forschung Toxicologie
- Weight at study initiation: 153 - 200g
- Housing: single housing
- Diet (e.g. ad libitum): ad libitum, ALTROMIN 1324 Atltogge Lage/Lippe
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 30 cm²
- Type of wrap if used: covered with aluminium foil and elastic patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 24 hours, rinsed with warm water - Duration of exposure:
- 24 h
- Doses:
- 1000, 2500, 3150, 4000 and 5000 mg/kg
- No. of animals per sex per dose:
- 6
- Details on study design:
- - Duration of observation period following administration: 14 - 21 days
- Other examinations performed: clinical signs, pathology - Statistics:
- Linder & Weber; Cavalli-Sforza
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 235 mg/kg bw
- Mortality:
- 1000 mg/kg: 0/6
2500 mg/kg: 1/6
3150 mg/kg: 1/6
4000 mg/kg: 6/6
5000 mg/kg: 6/6 - Clinical signs:
- other: Animals found dead died in a narcotic like condition in abdominal position. The skin on the back was dicoloured brown,hard and necrotic.
- Gross pathology:
- sacrificed animals: no abnormality
animals found dead: 5000 mg/kg: 3 dead animals showed pale spotted liver and a bloody small intestine. Regarding to autolytic changes, no macroscopic assessement of the other dead animals was possible.
Applicant's summary and conclusion
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