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EC number: 279-013-0 | CAS number: 78948-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study (not GLP compliant) without analytical monitoring. These are only a minor shortcoming and do not affect the overall significance of the findings.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at this time, but report has been reviewed by the testing facilities Quality Assurance Unit
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout (Oncorhynchus mykiss Walbaum 1792, former scientific name: Salmo gardneri)
- Source: Bibury Trout Farm, Gloucestershire, Great Britain
- Length at study initiation: 23.9 +/- 0.13 mm
- Weight at study initiation: 158 +/- 34 mg
ACCLIMATION
- Type and amount of food during acclimation: Mixed diet of hens' eggs and proprietary trout feed (B.P. Nutrition U.K. Ltd., Mainstream trout diet) - Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- extended up to 168 hours
- Hardness:
- 250 - 300 mg/l as calcium carbonate
- Test temperature:
- 13.5 - 15 °C
- pH:
- 6.7 – 7.6
- Dissolved oxygen:
- 7.9 – 9.5 mg/L
- Nominal and measured concentrations:
- Control, 8.03, 12.8, 20.0, 31.7, 52.2, 80.3, 128, 200, 317, 522, 803, 1284, 2000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 2 L borosilicate glass flasks
- Renewal rate of test solution: 20 mL/min
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Deep well in the Hertfordshire chalk
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 13:11 hours light:dark cycle
EFFECT PARAMETERS MEASURED:
After 24, 48, 96 and 168 hours mortality, at this time also pH and oxygen content were recorded - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 31.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 56 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CI: 43.2-76.6 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 128.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Reported statistics and error estimates:
- Calculation of median lethal concentration (LC50) after 12, 24, 48, 96 and 168 hours, using methods described by Litchfield JT (1949) and Litchfield LT & Wilcoxon F (1949)
- Sublethal observations / clinical signs:
Nominal [mg/L]
Mortality after 96 h [%]
Mortality after 168 h [%]
Control
0
0
12.8
0
0
20
0
20
31.7
0
90
52.2
60
100
80.3
80
100
128.4
100
100
In concentrations of 200 mg/L and higher no fish survived the first day, therefore these results are not listed in the table above.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test results indicate that MMPP is acutely harmful towards fish
- Executive summary:
The acute toxicity of MMPP towards fish was performed according to the OECD guideline 203 (1984). Rainbow trout O. mykiss was used as test organism.
Ten fish were exposed to each of the 13 concentrations of the test substance between 8.3 and 2000 mg/L and to a control. The test was performed at 15 °C. Test duration was 168 hours and survival was assessed troughout this period in variable intervals. pH and dissolved oxygen concentrations were also measured.
H48 BLEACH was found to be toxic towards fish. A clear concentration-response relationship can be deduced from the study results. The numerical results for acute toxicity are given below. Additionally, after 168 hours an LC50 of 38.5 mg/L has been obtained.
Analytical monitoring of test concentration was not performed. Volatility and adsorption of MMPP from aqueous solutions can be neglected and therefore these properties have no influence on the result. However, MMPP hydrolyses in aqueous solution and MMPP is regarded as readily biodegradable; both effects may reduce the nominal concentration. Nevertheless, an analytical monitoring is not necessary, as the aqueous solution of MMPP reflects the emission of hydrolyses products to aquatic organisms. Furthermore, the biodegradability is assumed to have only minor effects on the results due to the relatively short test duration. The concentration in aqueous solution is assumed to be sufficiently stable under the test conditions due to the analytical results shown in the algae growth inhibition test.
All validity criteria according the test guideline OECD 203 are met within the study.
Reference
Description of key information
The acute toxicity of MMPP towards fish was performed according to the OECD guideline 203 (1984). Rainbow troutO. mykisswas used as test organism.
Test duration was 168 hours and survival was assessed troughout this period in variable intervals. pH and dissolved oxygen concentrations were also measured.
H48 BLEACH was found to be toxic towards fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 56 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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