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Registration Dossier
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EC number: 236-860-0 | CAS number: 13518-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
The substance diphosphoric acid, compound with 1,3,5-triamine (1:2) is a solid salt that dissociates in aqueous environments forming melamine and pyrophosphate ions. The experimentally determined water solubility of the substance is 385.6 ± 1.1 mg test item/L based on P and 233.1 ± 2.4 mg/L based on non purgeable carbon (OECD 105). Experimental data on the ready biodegradability of diphosphoric acid, compound with 1,3,5-triamine (1:2) are not available. Based on the expected dissociation in water the degradation of the substance compounds melamine and pyrophosphate is assessed separately. In the available read across study, testing the ready biodegradability of melamine, no biodegradation of the substance was observed under test conditions (OECD 301C; NITE, 2010). However, a rapid degradation of melamine by adapted activated sludge microorganisms in industrial sewage treatment plants (STPs) has been demonstrated by Fimberger (1997). The second dissociation product pyrophosphate is an inorganic substance and thus the concept of biodegradation is not applicable and no data are included in the dossier. Abiotic degradation by hydrolysis in water is no relevant degradation pathway for melamine since the molecule comprises no hydrolysable functional groups. The pyrophosphate ion undergoes further hydrolysis and is ultimately converted into orthophosphate ions. Bioaccumulation or adsorption of diphosphoric acid, compound with 1,3,5-triamine (1:2) is not expected due the experimentally determined low log Pow (log Pow -1.24 at 20 °C, OECD 107). Furthermore the substance is not volatile and thus accumulation in the air and subsequent transport to other environmental compartments is not likely. Thus, if released to the environment, the substance will presumably distribute mainly to natural water bodies. Persistence in this compartment cannot be excluded based on the available data on ready biodegradability. However, a degradation of melamine via nitrification in soil is possible even though the DT50 was derived to be > 2 to < 3 years (Hauck, 1964). Phosphate is ubiquitous in the environment and an essential micronutrient for many organisms. Inorganic phosphates will dissociate to soluble orthophosphate (PO43-) in sewerage systems, sewage treatment plants and in the environment. These same orthophosphates are also formed by natural hydrolysis of human urine and faeces, animal wastes, food and organic wastes, mineral fertilisers, bacterial recycling of organic materials in ecosystems, etc. The phosphate anion in soil will precipitate with Fe, Al or Ca cations. Thus, the mobility of phosphate in soil is limited. In natural water bodies phosphates are bio-assimilated by bacteria, aquatic plants and algae. Phosphates are an essential nutrient (food element) for plants, and stimulate the growth of water plants (macrophytes) and/or algae (phytoplankton) if they represent the growth-limiting factor.
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