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Toxicological information

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Description of key information

No skin sensitisation study with strontium bis(2-ethylhexanoate) is available, thus the skin sensitisation potential will be addressed with existing data on the individual moieties strontium and 2‑ethylhexanoic acid.

Strontium bis(2-ethylhexanoate) is not expected to show signs of dermal sensitisation, since the two moieties strontium and 2‑ethylhexanoic acid have not shown any skin sensitisation potential in experimental testing.

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Strontium

A Guinea pig maximisation test according to OECD Guideline 406 conducted with the test substance is considered to be reliable without restrictions. The results showed that the test item has no skin sensitisation potential.

2-ethylhexanoic acid

In a guinea pig maximization assay (Berol Kemi AB, 1979), 0/10 female Dunkin-Hartley guinea pigs exhibited a response 48 h after induction and challenge with 5 % (w/w) and 2 % (w/w) aqueous 2‑ethylhexanoic acid solution, respectively. The intracutaneous injections were performed with 1 % (w/w) aqueous 2-ethylhexanoic acid solution. In summary, there is no evidence of a notable sensitization potential of 2-ethylhexanoic acid.

 

Strontium bis(2-ethylhexanoate)

Strontium bis(2-ethylhexanoate) is not expected to have a skin sensitising activity, since the two moieties strontium and 2-ethylhexanoic acid have not shown any skin sensitisation potential in experimental testing. Further testing is not required. For further information on the toxicity of the individual moieties, please refer to the relevant sections in the IUCLID and CSR.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

As the two moieties of strontium bis(2-ethylhexanoate) are not sensitising, strontium bis(2-ethylhexanoate) in all probability has also no sensitising activity. According to the criteria of REGULATION (EC) No 1272/2008 and its subsequent adaptions, strontium bis(2-ethylhexanoate) does not have to be classified and has no obligatory labelling requirement for sensitization by skin contact.