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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Assessed after consultation with the relevant Authority. Data migrated from NONS (67/548/EEC notification) files provided by Authority contained insufficient information.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: U.S. EPA Pesticide Assessment Guidelines, Subdivision F, Part 81-5.
GLP compliance:
yes
Remarks:
No further information was provided in the SNIF file.

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
EC Number:
411-290-7
EC Name:
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
Cas Number:
131538-00-6
Molecular formula:
C7 H16 S5
IUPAC Name:
2,3-bis((2-mercaptoethyl)thio)-1-propanethiol
Details on test material:
- Analytical purity: no data

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
500 mL
Duration of treatment / exposure:
4 hours
Observation period:
14 days
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
1.67
Max. score:
4
Reversibility:
not fully reversible within: 14 days
Remarks on result:
other: Maximum duration of effect: 14 days. Maximum score at the end of the observation period: 1
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0.33
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritant / corrosive response data:
Reversibility of any observed effects: Changes not fully reversible within 14 days.
Other effects:
No unusual necropsy results.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to Annex VI of DSD (67/548/EEC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are conclusive but not sufficient for
classification.
According to Annex I of CLP (1272/2008/EC), the available data on 2,3-bis((mercaptoethyl)thio)-1-propanethiol are conclusive but not sufficient
for classification.