Registration Dossier

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeClas tool

Data source

Reference
Reference Type:
other: software
Title:
Unnamed
Year:
2020

Materials and methods

Principles of method if other than guideline:
Eye irritation potential of pNMC oxide (generic composition) was determined by classifying based on the Mixture rules from EU CLP (additivity formula of classified components to derive hazard class) and back calculation to the corresponding acute toxicity range estimate.

Test material

1
Reference substance name:
Nickel Cobalt Manganese Hydroxide
EC Number:
839-353-8
Cas Number:
189139-63-7
Molecular formula:
Molecular formula: Ni1-x-yMnxCoy(OH)2, Stoechiometry of (Me = Ni + Co + Mn) equals 1, ranges of the elements approx. as: Ni/Me = 0.25 – 0.95 Mn/Me = 0.02 – 0.40 Co/Me = 0.02 – 0.40 OH = 2.00
IUPAC Name:
Nickel Cobalt Manganese Hydroxide
Constituent 1
Chemical structure
Reference substance name:
Manganese dihydroxide
Cas Number:
18933-05-6
Molecular formula:
Mn(OH)2
IUPAC Name:
Manganese dihydroxide
Constituent 2
Chemical structure
Reference substance name:
Cobalt dihydroxide
EC Number:
244-166-4
EC Name:
Cobalt dihydroxide
Cas Number:
21041-93-0
Molecular formula:
CoH2O2
IUPAC Name:
cobalt(2+) dihydroxide
Constituent 3
Chemical structure
Reference substance name:
Nickel dihydroxide
EC Number:
235-008-5
EC Name:
Nickel dihydroxide
Cas Number:
12054-48-7
Molecular formula:
H2NiO2
IUPAC Name:
nickel(2+) dihydroxide
Test material form:
solid: particulate/powder

Results and discussion

In vitro

Results
Irritation parameter:
other: Calculation by MeClas
Remarks on result:
other: mixture rules, based on the hazartd properties of the constituents
Other effects / acceptance of results:
It was calculated that the substance pNMC oxide was not irritant to the eye.

Applicant's summary and conclusion

Conclusions:
An Eye Irrit. Cat.2 classification was determined theoretically with MeClas

Categories Display