Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Skin irritation/corrosivity:

A GLP-compliant in-vitro skin corrosivity test was conducted in accordance with the requirements of OECD Guideline 431 and EU Method B.40 BIS (Warren, 2012b). Data were presented in the form of percentage viability (MTT reduction in the test item treated tissues relative to negative control tissues). The relative mean viability of the test item treated tissues was as follows: 240 minutes exposure, 12.1%; 60 minutes exposure, 21.4%; 3 minutes exposure, 54.4%. On this basis it is concluded that copper di(acetate) is corrosive in contact with skin and that the following classification applies:

  • According to Directive 67/548/EEC: Corrosive (C). R34, Causes burns.
  • According to CLP/GHS: Category 1B Corrosive, H314, Causes severe skin burns and eye damage.


Eye irritation/corrosivity:

A GLP-compliant eye irritation test was carried out in a single rabbit in accordance with internationally accepted guidelines (Bradshaw, 2012c). The persistence of reactions in the treated eye at the 21 -Day observation was considered to be indicative of irreversible ocular damage. The test item was considered to be corrosive to the rabbit eye and was classified as follows:

  • According to Directive 67/548/EEC: Irritant (Xi). R41, risk of serious damage to eyes.
  • According to CLP/GHS: Eye Damage 1, H318: Causes serious eye damage.


Justification for classification or non-classification