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EC number: 205-553-3
CAS number: 142-71-2
The persistence of reactions in the treated eye at the 21-Day
observation was considered to be indicative of irreversible ocular
See Table 2 (attached) for detailed occular irritation scores.
See Table 3 (attached) for individual bodyweights and bodyweight change.
A GLP-compliant study was performed to assess the irritancy potential of
the test item to the eye of the New Zealand White rabbit. The
method was designed to be compatible with OECD Guideline 405 and EU
Method B5. A single application of the test item to
the non-irrigated eye of one rabbit produced translucent corneal
opacity, iridial inflammation, moderate conjunctival irritation and
vascularisation, with a generalised ingrowth of vessels for up to 2 mm. The
persistence of reactions in the treated eye at the
21-Day observation was considered to be indicative of irreversible
The test item was considered to be corrosive to the rabbit eye and was
classified as Irreversible effects on the eye (Category 1). The Signal
Word “Danger” and the Hazard Statement “H318: Causes serious eye damage”
are therefore required.
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