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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1990
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: reference data from SNIF file

Data source

Referenceopen allclose all

Reference Type:
other: SNIF data provided by ECHA
Title:
Unnamed
Year:
1990
Report date:
1990
Reference Type:
secondary source
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17 H14 O
IUPAC Name:
2-(benzyloxy)naphthalene

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 mL (0.065 g)
Duration of treatment / exposure:
unspecified (no rinsing reported)
Observation period (in vivo):
not reported
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
2
Reversibility:
other: no effects
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
3
Reversibility:
not fully reversible within: 3 d
Remarks on result:
other: One hour after exposure, only slight redness of the conjunctivae were reported. Average Draize scores were 0.33 for the 1 hour reading.
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24 - 72 h
Score:
0
Max. score:
4
Reversibility:
not fully reversible within: 3 d
Remarks on result:
other: One hour after exposure, only slight edema of the conjunctivae were reported. Average Draize scores were 0.33 for the 1 hour reading.
Irritant / corrosive response data:
One hour after exposure, slight ocular discharge were reported. Average Draize scores were 0.33.

Applicant's summary and conclusion

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