Registration Dossier
Registration Dossier
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EC number: 213-243-4 | CAS number: 931-87-3
Toxicity to other above-ground organisms
Administrative data
Link to relevant study record(s)
Description of key information
The derivation of the PNECoral is related to the assessment of secondary poisoning. A study on mammals is not required due to the lack of exposure. However, based on the mammalian toxicity data, cis-cyclooctene is not classified as very toxic (T+), Toxic (T) or harmful (Xn) and does not carry the risk phrases R48, R60, R62, R63 or R64. No adverse effects were noted in a 28-day oral gavage study with rats, the NOAEL was 150 mg/kg bw/d. Furthermore in a published study the formation of sulfur containing metabolites in female rabbits and rats was investigated. More than 80% of the administered dose of 2 mmol cyclooctene (220mg)/kg bw was excreted within 24h as sulfur containing metabolites indicating extensive absorption and extensive metabolism including hydroxylation as well as rapid excretion. Based on this study result no bioaccumulation potential can be observed. Based on these data no PNECoral needs to be calculated
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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