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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Toxicity to other above-ground organisms

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Administrative data

Link to relevant study record(s)

Description of key information

The derivation of the PNECoral is related to the assessment of secondary poisoning. A study on mammals is not required due to the lack of exposure. However, based on the mammalian toxicity data, cis-cyclooctene is not classified as very toxic (T+), Toxic (T) or harmful (Xn) and does not carry the risk phrases R48, R60, R62, R63 or R64. No adverse effects were noted in a 28-day oral gavage study with rats, the NOAEL was 150 mg/kg bw/d. Furthermore in a published study the formation of sulfur containing metabolites in female rabbits and rats was investigated. More than 80% of the administered dose of 2 mmol cyclooctene (220mg)/kg bw was excreted within 24h as sulfur containing metabolites indicating extensive absorption and extensive metabolism including hydroxylation as well as rapid excretion. Based on this study result no bioaccumulation potential can be observed. Based on these data no PNECoral needs to be calculated

Key value for chemical safety assessment

Additional information