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EC number: 213-243-4
CAS number: 931-87-3
In a reverse gene mutation assay in bacteria, strains TA98, TA100,
TA1535, TA1537 and TA1538 of Salmonella typhimurium were exposed
to Cis-cyclooctene using acetone as a vehicle at concentrations of 8,
40, 200, 100 and 5000 µg/plate, with and without S-9 activation in a
preincubation assay according to EEC guidance Dir. 84/449/EEC, B.14.
The test article was tested at six dose levels along with
appropriate vehicle and positive controls on the tester strains
mentioned above in the presence and absence of S9-mix. All dose levels,
vehicle and positive controls were plated in triplicate.
Cytotoxicity was noted in the absence of
S9 mix at the highest concentration for TA 1535 and TA1537.
No positive mutagenic responses were
observed with any of the strains used, in the presence as well as in the
absence of microsomal enzymes. These results were confirmed in an
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