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EC number: 213-243-4
CAS number: 931-87-3
Studies on acute toxicity by the oral route and by the dermal route in rats and mice demonstrated that z-cyclooctene is practically non toxic. Using a read across approach an LC50 estimated based on data for cyclohexene.
Z-Cyclooctene was demonstrated to be practically non-toxic upon a single
dose by the oral or dermal route.
Considering that oral absorption of z-cyclooctene is extensive and
taking into account that repeated inhalation of the analogous cyclic
alkene cyclohexene resulted in no mortalities at 600 ppm (2.015 mg/m³ =
26.8 mmol/m³) upon 6 month exposure is concluded that the LC50 for
z-cyclooctene exceeds 26.8 mmol/m³ corresponding to 3000 mg/m³.
Due to the effect levels obtained in the acute toxicity studies, no
classification according to EU and GHS criteria is required.
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