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Administrative data

Description of key information

Studies on acute toxicity by the oral route and by the dermal route in rats and mice demonstrated that z-cyclooctene is practically non toxic. 
Using a read across approach an LC50 estimated based on data for cyclohexene.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
4 550 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
3 000 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
10 000 mg/kg bw

Additional information

Z-Cyclooctene was demonstrated to be practically non-toxic upon a single dose by the oral or dermal route.

Considering that oral absorption of z-cyclooctene is extensive and taking into account that repeated inhalation of the analogous cyclic alkene cyclohexene resulted in no mortalities at 600 ppm (2.015 mg/m³ = 26.8 mmol/m³) upon 6 month exposure is concluded that the LC50 for z-cyclooctene exceeds 26.8 mmol/m³ corresponding to 3000 mg/m³.

Justification for classification or non-classification

Due to the effect levels obtained in the acute toxicity studies, no classification according to EU and GHS criteria is required.