Registration Dossier
Registration Dossier
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EC number: 213-243-4 | CAS number: 931-87-3
Endpoint summary
Administrative data
Description of key information
Studies on acute toxicity by the oral route and by the dermal route in rats and mice demonstrated that z-cyclooctene is practically non toxic.
Using a read across approach an LC50 estimated based on data for cyclohexene.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 4 550 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 3 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Additional information
Z-Cyclooctene was demonstrated to be practically non-toxic upon a single dose by the oral or dermal route.
Considering that oral absorption of z-cyclooctene is extensive and taking into account that repeated inhalation of the analogous cyclic alkene cyclohexene resulted in no mortalities at 600 ppm (2.015 mg/m³ = 26.8 mmol/m³) upon 6 month exposure is concluded that the LC50 for z-cyclooctene exceeds 26.8 mmol/m³ corresponding to 3000 mg/m³.
Justification for classification or non-classification
Due to the effect levels obtained in the acute toxicity studies, no classification according to EU and GHS criteria is required.
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