Registration Dossier
Registration Dossier
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EC number: 201-756-6 | CAS number: 87-60-5
Specific investigations: other studies
Administrative data
- Endpoint:
- methaemoglobinaemia
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
- Author:
- Gesellschaft Deutscher Chemiker
- Year:
- 1 990
- Bibliographic source:
- Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
- Reference Type:
- publication
- Title:
- Biomonitoring of aromatic amines. II. Hemoglobin binding of some monocyclic aromatic amines.
- Author:
- Bierner and Neumann
- Year:
- 1 988
- Bibliographic source:
- Arch. Toxicol. 62, pp. 110-115
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Measurement of methaemglobin after oral application of test substance in rats.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- acute toxicity: oral
Test material
- Reference substance name:
- 5-chloro-o-toluidine
- EC Number:
- 202-452-6
- EC Name:
- 5-chloro-o-toluidine
- Cas Number:
- 95-79-4
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 5-chloro-2-methylaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- single treatment
- Frequency of treatment:
- once
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
85 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Examinations
- Examinations:
- measurement of methaemglobin 1.5 hours after application
Results and discussion
- Details on results:
- Maximal methaemglobin level of 2.0 ± 0.4% was observed.
Applicant's summary and conclusion
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