Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
methaemoglobinaemia
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
Gesellschaft Deutscher Chemiker
Year:
1990
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
Reference Type:
publication
Title:
Biomonitoring of aromatic amines. II. Hemoglobin binding of some monocyclic aromatic amines.
Author:
Bierner and Neumann
Year:
1988
Bibliographic source:
Arch. Toxicol. 62, pp. 110-115

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Measurement of methaemglobin after oral application of test substance in rats.
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
acute toxicity: oral

Test material

Constituent 1
Chemical structure
Reference substance name:
5-chloro-o-toluidine
EC Number:
202-452-6
EC Name:
5-chloro-o-toluidine
Cas Number:
95-79-4
Molecular formula:
C7H8ClN
IUPAC Name:
5-chloro-2-methylaniline

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
single treatment
Frequency of treatment:
once
Post exposure period:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
85 mg/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
3
Control animals:
not specified

Examinations

Examinations:
measurement of methaemglobin 1.5 hours after application

Results and discussion

Details on results:
Maximal methaemglobin level of 2.0 ± 0.4% was observed.

Applicant's summary and conclusion