Registration Dossier
Registration Dossier
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EC number: 211-951-8 | CAS number: 719-80-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented non guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was performed in principle as described in OECD test guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20°C. Young adult laboratory rats, 3 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 h. Every 30minutes, the glass cylinder was exchanged against one containing fresh substance. No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure. Group-wise documentation of clinical signs was performed over a 14 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period.
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl diphenylphosphinite
- EC Number:
- 211-951-8
- EC Name:
- Ethyl diphenylphosphinite
- Cas Number:
- 719-80-2
- Molecular formula:
- C14H15OP
- IUPAC Name:
- ethyl diphenylphosphinite
- Details on test material:
- - Name of test material (as cited in study report): Diphenylethoxyphosphin
- Physical state: colorless liquid
- Analytical purity: 95.4%
- Expiration date of the lot/batch: 02/1983
- Storage condition of test material: 5°C under oxygen exclusion
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Thomae GmbH, Biberach
- Age at study initiation: 8 weeks
- Weight at study initiation: males (average): 231g, females (average): 173g
- Housing: groups of 3 in steel cages (Becker, D III)
- Diet (e.g. ad libitum): SSNIFF ad lib.
- Water (e.g. ad libitum): app. 250ml tap water daily
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-2°C
- Humidity (%): 55 +/- 5%
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Method of holding animals in test chamber: closed glass tubes
- Source and rate of air: No source mentioned; 200 L/h
- Treatment of exhaust air: discarded, no treatment mentioned
TEST ATMOSPHERE
- Brief description of analytical method used: no analytics performed
- Samples taken from breathing zone: no - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- saturated air
the weight/substance loss of the storage container was determined and the concentration in air was estimated as <0.04mg/l - No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily oberservations for lethality, week-daily for clinical signs
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- < 0.04 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: no mortality when exposed to saturated air
- Mortality:
- no mortality observed
- Clinical signs:
- other: no clinical signs observed
- Body weight:
- no data
- Gross pathology:
- no findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- A saturated atmosphere of the substance did not lead to any mortality in rats after a single 7h exposure.
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