Registration Dossier
Registration Dossier
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EC number: 211-951-8 | CAS number: 719-80-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- adopted May 12th, 1981
- GLP compliance:
- no
Test material
- Reference substance name:
- Diphenylethoxyphosphin
- IUPAC Name:
- Diphenylethoxyphosphin
- Reference substance name:
- Ethyl diphenylphosphinite
- EC Number:
- 211-951-8
- EC Name:
- Ethyl diphenylphosphinite
- Cas Number:
- 719-80-2
- Molecular formula:
- C14H15OP
- IUPAC Name:
- ethyl diphenylphosphinite
- Details on test material:
- - Name of test material (as cited in study report): Diphenylethoxyphospin
- physical state: liquid
- Analytical purity: no data
- Expiration date of the lot/batch: October 1982
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach/Main
- Age at study initiation: no data
- Weight at study initiation: male: 3.13kg, females 3.3kg, 3.27kg
- Housing: single in steel cages (40cm x 51cm)
- Diet (e.g. ad libitum): Ovator Solikanin 4mm, app. 130g per animal and day
- Water (e.g. ad libitum): app. 250ml per animal and day (VE water on weekdays, tap water on weekends)
- Acclimation period: app. 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%):app. 30-70%
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1ml - Observation period (in vivo):
- 72h (1h, 24h, 48h, 72h after application)
- Number of animals or in vitro replicates:
- 1 male, 2 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- substance not washed out
SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24h-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24h-72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24h-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72h
- Remarks on result:
- other: slight discharge in animal no.1
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 3
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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