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Diss Factsheets

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003
Report date:
2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 C (Bioaccumulation: Test for the Degree of Bioconcentration in Fish)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclododeca-1,5,9-triene
EC Number:
225-533-8
EC Name:
Cyclododeca-1,5,9-triene
Cas Number:
4904-61-4
Molecular formula:
C12H18
IUPAC Name:
cyclododeca-1,5,9-triene
Details on test material:
IUCLID4 Test substance: other TS: 1,5,9-cyclododecatriene, purity 94 % (trans, trans, trans form)
Origin: Tokyo Kasei Kogyo Co., Ltd.
Radiolabelling:
no

Sampling and analysis

Details on sampling:
- Sampling in weeks 1, 2, 4, 6, 8 and 10 (both fish and water)

Test solutions

Vehicle:
yes
Details on preparation of test solutions, spiked fish food or sediment:
- Vehicle / dispersant: HCO-20, HCO-40

Test organisms

Test organisms (species):
Cyprinus carpio
Details on test organisms:
TEST ORGANISMS
- Size of fish: average weight 26.2 g, average total length 9.8 cm
- Lipid content of test organism: 5 % average

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
70 d

Test conditions

Test temperature:
25 °C +/- 1 °C
Details on test conditions:
EXPOSURE CONDITIONS
- Exposure vessel: 100 l glass tank, 1155 l/day flow-through

- Results based on measured concentrations in water
Nominal and measured concentrations:
Concentration of test substance: 1 µg/l, 10 µg/l (nominal)
Reference substance (positive control):
no

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
2 630 - 12 500
Basis:
whole body w.w.
Remarks on result:
other: Conc.in environment / dose:10 µg/L
Type:
BCF
Value:
1 920 - 14 800
Basis:
whole body w.w.
Remarks on result:
other: Conc.in environment / dose:1 µg/L
Depuration
Elimination:
no

Any other information on results incl. tables

- Measured vs nominal concentrations:
  nominal:    1      2      4      6      8     10 weeks
  10 ug/l: 5.54   5.59   6.12   6.49   6.90   6.95 ug/l
   1 ug/l: 0.442  0.511  0.576  0.617  0.650  0.666 ug/l
- Bioconcentration factors
  Range at 10 ug/l: BCF 2630-12500
  Range at  1 ug/l: BCF 1920-14800
  (2 determinations for each concentration and each time point listed above)

Applicant's summary and conclusion

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