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EC number: 225-533-8
CAS number: 4904-61-4
RESULTS OF TEST
- Sensitization reaction: 2/20 animals showed a sensitization 24 hours, 1/20 animals 48 hours after challenge
= slight sensitization (no classification)
- Clinical signs: After intracutaneous application, the following signs were observed in the places of application:
FCA treatment: intense erythema and edema as well as necroses;
Test substance treatment: slight erythema and edema;
Vehicle treatment: slight redness
After removal of the induction patch, severe inflammation with discharge of matter and in some cases blood was
observed in the
FCA treatment positions.
In a guinea pig maximization test performed with the test 1,5,9
-cyclododecatriene, after intradermal and epidermal inductions and 24
hours as well as 48 hours after epidermal challenge, two (48h) and one
(24h) of the 20 animals examined in this study, showed positive response
regarding dermal sensitization.
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