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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

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Description of key information

Parent substance EC 401 -280 -0


The results of the Hydrolysis study (Ciba, 2009) show that the test item hydrolyses rapidly in water. The study includes two sets of experiments (Investigation by LC/MS and investigation by H-NMR). Both experiments showed that hydrolysis of the test item is very fast. The proposed degradation products are bis(2 -ethylhexyl)amine, 1H-1,2,4 -triazole and formaldehyde (as methanediol).


The ready biodegradability of the test item was assessed according to OECD guideline 301B. The test revealed that no biodegradation occurred. Additionally the chemical oxygen demand was investigated according to DIN 38 409. A COD of 2.55 g COD/g test substance was calculated.


Due to the results from different QSAR calculations significant bioaccumulation is not expected.

Transport and distribution

No reliable data on substance EC 401 -280 -0 are available. However, as this substance hydrolyses very fast only the degradation products are considered.

Environmental fate data on the degradation products were additionally evaluated. After hydrolysis, the degradation products will consist mainly of bis(2-ethylhexyl)amine (ca 70%), about 20% of the hydrolysate will be 1H-1,2,4-triazole and about 10% formaldehyde (taking into account the individual molecular masses).

Hydrolysis products:

bis(2 -ethylhexyl)amine


Due to the structural properties of the substance, hydrolysis is not expected under environmental conditions.


The test substance is regarded to be not readily biodegradable, but moderately biodegradable.


Significant accumulation in organisms is not expected.

Transport and distribution

Adsorption to the solid soil phase is expected.

From the water surface, the substance will slowly evaporate into the atmosphere at pH 9.0 but not at pH 7.0 and lower.

According to the results of the Mackay LEVEL 1 calculation, over time the substance will preferentially distribute into the compartments sediment (50%) and soil (50%). However, since the model does not consider the ionic form of the molecule at environmental relevant pH conditions (5 -9), the model may underestimate distribution into water.

1H-1,2,4 -triazole


The hydrolysis half-life of 1H-1,2,4 -triazole is > 30days (ECHA disseminated REACH dossier, 2014).


The substance is not readily biodegradable but significant degradation was observed in a field study in different soils (ECHA disseminated REACH dossier, 2014).


Due to the results of QSAR calculations, significant accumulation in organisms is not expected. The log Pow of -0.58 (Hansch et al 1995) indicates a low bioaccumulation potential.

Transport and distribution

Mobility in soil is expected. No data on Henry's Law constant and distribution modelling are available.



Hydrolysis is not expected due to the chemical structure.


Formaldehyde is expected to be readily biodegradable at low concentrations (Gerike 1990).


In tests on different fish species and a shrimp, no bioaccumulation was observed. The log Pow of 0.35 (Hansch et al 1995) indicates a low bioaccumulation potential.

Transport and distribution

Moderate to high mobility in soil is expected. From the water phase the substance will not evaporate into the atmosphere. Using simple environmental models based on fugacity, the main target for environmental distribution will be water.

Additional information