Registration Dossier
Registration Dossier
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EC number: 807-654-3 | CAS number: 1627851-18-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) = 101 mg a.i./L for Danio rerio (ISO 7346/1-3; read-across)
Key value for chemical safety assessment
Additional information
There are no data available on the short-term toxicity to fish of D-Glucopyranose, oligomeric, heptyl glycoside. However, there are reliable data for category member substances which are considered suitable for read-across based on a category approach. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.
Three studies investigated the short-term effects of D-Glucopyranose, oligomeric, hexyl glycosides (CAS: 54549-24-5) towards fish. The studies were performed with Scophthalmus maximus for the marine and Oncorhynchus mykiss for the freshwater compartment. The freshwater studies exhibited LC50 (96 h) values of > 100 mg/L and 420 mg/L, respectively (Safepharm Laboratories Limited, 1997 and 1998). These tests were performed according to OECD guideline 203. One test with marine species exhibited an LC50 (96 h) of 765 mg/L (M-Lab AS, 2004). This test was performed similar to “PARCOM Protocols on methods for the testing of chemicals used in the offshore industry. Part B: Protocol for a fish Acute toxicity test”.
Several tests for the evaluation of short-term effects of D-Glucopyranose, oligomers, decyl octyl glycosides (CAS: 68515-73-1) towards marine and freshwater fish were performed. Scophthalmus maximus and Cyprinodon variegatus were used for the marine and Brachydanio rerio for the freshwater compartment, respectively. The freshwater tests exhibited LC50 (96 h) values between 100.81 mg a.i./L and 126 mg a.i./L (Henkel KGaA / Department of Ecology, 1993 and 2008) and were performed according to “ISO 7346/1-3 (Determination of the Acute Lethal Toxicity of Substances to a Freshwater Fish [Brachydanio rerio Hamilton-Buchanan (Teleostei, Cyprinidae)])”. Tests with marine species exhibited LC(L)50 (96 h) values of 96.64 mg/L and 541.82 mg/L (prepared with water accommodated fraction without analytics) and a NOEC (96 h) of >= 21 mg/L (ERT (Orkney) Limited Orkney Water Technology Centre Flotta, 2001; Opus Plus Limited Flotta, 2007). The marine studies were performed according to “OSPARCOM (2005-11) protocol for a fish acute toxicity test” and “OECD 203 guideline as adapted by OSPARCOM (1995) for marine testing of offshore chemicals”.
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