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Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

NOEC (28 d) = 1.8 mg a.i./L for Brachydanio rerio (OECD 204; read-across)

Key value for chemical safety assessment

Additional information

There are no data available on the long-term toxicity to fish of D-Glucopyranose, oligomeric, heptyl glycoside. However, there are reliable data for category member substances which are considered suitable for read-across based on a category approach. This read-across is in accordance with Regulation (EC) No. 1907/2006 Annex XI, 1.5 and justified in detail in the overall summary (IUCLID Chapter 6.1) and within the category justification attached in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. Nevertheless, as it can be seen in the data matrix of the category justification in IUCLID Section 13 and the overall summary (IUCLID Chapter 6.1), all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.

One guideline study investigating the long-term toxicity of the category member D-Glucopyranose, oligomeric, C10-16-alkyl glycosides (CAS: 110615-47-9) to fish is available. The toxicity of the substance to the zebrafish Brachydanio rerio was tested in a prolonged fish toxicity test according to the OECD guideline 204 ("Fish, prolonged toxicity test: 14-day study") for 28 days (TNO Institute of Environmental Sciences, 1995). This test can be used as a long-term test because the following criteria are fulfilled: the duration is 28 days, the tested fish life stage is equal to OECD 215 and additional parameters like behaviour and growth were investigated (according to “Guidance Document on Aquatic Ecotoxicology” published by the European Commission (2002)). The test exhibited a NOEC of 1.8 mg a.i./L after 28 days for the endpoint mortality and a NOEC of 3.2 mg a.i./L for the endpoint growth, respectively. No behavioral abnormalities were observed in the non-toxic concentrations of the test substance.