Coconut oil, reaction products with polyethylene glycol and trimethylolpropane

Endpoint summary

Additional information

After exposure of Cyprinus carpio for 96 h with Coconut oil, reaction products with polyethylene glycol and trimethylolpropane the highest concentration at which no mortality (<=10 %) occurred was LC0 = 50 mg/L. After exposure for 96 h, the lowest concentration at which 100 % mortality occurred was LC100 = 202 mg/L. The LC50 after 96 h was 123 mg/L.For the structure-related substance coconut fatty acid mono- or diglyceride with trimethylolpropaneethoxylate the data were nearly equal. After exposure of Cyprinus carpio for 96 h, the highest concentration at which no mortality (<=10 %) occurred was LC0 = 50 mg/L, the lowest concentration at which 100 % mortality occurred was LC100 = 200 mg/L. The LC50 after 96 h was estimated graphically 112 mg/L.

After exposure of Daphnia magna with Coconut oil, reaction products with polyethylene glycol and trimethylolpropane for 48 h, the highest concentration in a static test according to 92/69/EEC at which no immobilization (<= 10 %) occurred was 15 mg/L, the LC100 > 124 mg/L (highest concentration), the EC50 = 81 mg/L. It is to be remarked that the testsubstance is due to its properties insoluble in water. The concentrations employed were in all cases emulsions.

The acute toxicity of the structural related substance Marlowet 4751 (coconut oil, reaction products of coconut fatty acid mono- or diglyceride with trimethylolpropaneethoxylate) to Daphnia magna was also investigated . After exposure for 48 h, the highest concentration at which no immobilization (<= 10 %) occurred was 12 mg/L, the LC100 > 100 mg/L (highest concentration), the EC50 was 32 mg/L (95 % confidence interval).

Coconut oil, reaction products with polyethylene glycol and trimethylolpropane is regarded as harmful to Daphnia magna.

The toxicity to algae was investigated with Coconut oil, reaction products with polyethylene glycol and trimethylolpropane. On the basis of growth rate, a mean effective concentration can be calculated to EC50 > 11.7 mg/L (the highest tested concentration), the EC10 was 7.8 mg/L. The NOEC based on cell growth was 5.9 mg/L. The testsubstance is due to its properties insoluble in water. The concentrations employed were in all cases emulsions. For the structural related substance Marlowet 4751 (coconut oil, reaction products of coconut fatty acid mono- or diglyceride with trimethylolpropaneethoxylate were found similar results. On the basis of growth rate, a mean effective concentration of the structural related substance) can be calculated to EC50 = 25 mg/L. The NOEC based on biomass was 5.0 mg/L.

An OECD 211 -study was performed to assess the chronic toxicity of Coconut oil, reaction products with polyethylene glycol and trimethylolpropane

to Daphnia magna. The 21-Day EL50 (immobilization) value, based on nominal loading rates, for the parental Daphnia generation (P1) was calculated to be 18 mg/L loading rate WAF. The 21-Day EL50 (reproduction) based on nominal loading rates was 12 mg/L loading rate WAF. The "Lowest Observed Effect Loading Rate" (LOEL) and the "No Observed Effect Loading Rate" (NOEL) based on nominal loading rates were 10 and 3.2 mg/L loading rate WAF respectively. The "Maximum Acceptable Toxicant Loading Rate" (MATL) was calculated to be 5.7 mg/L loading rate WAF. Given that the toxicity cannot be attributed to a single component or a mixture of components, but to the test item as a whole, the results were based on nominal loading rates only.

Hence, Coconut oil, reaction products with polyethylene glycol and trimethylolpropane is regarded as harmful to algae and Daphnia and as practically non-toxic to fish.

Marlowet 4753 (Coconut oil, reaction products with polyethylene glycol and trimethylolpropane) was tested in Activated Sludge Respiration Inhibition Test according to EC guideline 88/302/EC. Within the tested concentrations of 57.4; 92.8; 189.4; 290.8 and 380 mg/L there were no significant toxic effects. The determined positive effects were not proportional to increasing concentration. The EC50 was > 370 mg/L rounded up to two significant places.

The structural related test substance coconut oil, reaction products of coconut fatty acid mono- or diglyceride with trimethylolpropaneethoxylate did not affect the bacterial respiration in the tested concentration range up to the highest used concentration: EC10 > 100 mg/L and therefore the EC50 is > 100 mg/L.

Justification for read-across: For aquatic toxicity results of the structural similar substance coconut oil, reaction products of coconut fatty acid mono- or diglyceride with trimethylolpropaneethoxylate are used, however, only supportive. The substance is very similar to the test substance, the difference is mainly that in the test substance also the triglyceride is present.