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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
not specified
Principles of method if other than guideline:
In principle the methods described in OECD Guideline 203 were used.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
yes
Details on test solutions:
FAT 36052/D was dissolved with acetone and in parallel and in another experiment FAT 36052/D was dissolved in Tween 80.
Test organisms (species):
other: Trout
Details on test organisms:
8 Trouts for each experiment.
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
48 h
Test temperature:
14 °C
pH:
8-8.1
Nominal and measured concentrations:
Nominal concentration used for FAT 36052/D dissolved with acetone and dissolved with Tween 80:
2 mg/l
20 mg/l
100 mg/l (Sediment)
200 mg/l
1000 mg/l
Details on test conditions:
8 trouts were used for the experiment where FAT 36052/D was dissolved with acetone and 8 trouts were used in the experiment where FAT 36052/D was dissolved with Tween 80.
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
LC0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Duration:
48 h
Dose descriptor:
LC100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Details on results:
- No mortality after 48h in the experiment where FAT 36052/D is dissolved with acetone (8/8 are alive)
- No mortality after 48h in the experiment where FAT 36052/D is dissolved with Tween 80 (8/8 are alive)
Validity criteria fulfilled:
yes
Conclusions:
In conclusion, the result for FAT 36052/D dissolved in acetone and for FAT 36052/D dissolved in Tween 80 are:
*LC 0 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC 50 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC100 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
Executive summary:

The acute fish toxicity study experiment was done with 8 fishes for each experiment (first FAT 36052/D is dissolved with Tween 80 and in the second, FAT 36052/D is dissolved with acetone)

The Temperature was 14 °C for both experience.

During the test, the pH was between 8 and 8.1.

At concentration 100 mg/L, 200 mg/L and 1000 mg/L of FAT 36052/D all fishes were alive at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).

In conclusion:

*LC 0 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)

*LC 50 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)

*LC100 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)

Description of key information

In all the three studies performed at concentration ranging from 3 mg/L to 1000 mg/L of FAT 36052/D there was no mortality noted at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 000 mg/L

Additional information

At Ciba Geigy AG acute fish toxicity testing was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1981. These methods were comparable to today’s standard testing procedure published by the OECD within Guideline for Testing of Chemicals 203: Fish, Acute Toxicity Test, adopted by the Council on 17thJuly 1992.

In all the three studies performed at concentration ranging from 3 mg/L to 1000 mg/L of FAT 36052/D there was no mortality noted at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).