Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 248-882-8 | CAS number: 28173-59-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- In principle the methods described in OECD Guideline 203 were used.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- FAT 36052/D was dissolved with acetone and in parallel and in another experiment FAT 36052/D was dissolved in Tween 80.
- Test organisms (species):
- other: Trout
- Details on test organisms:
- 8 Trouts for each experiment.
- Test type:
- not specified
- Water media type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 14 °C
- pH:
- 8-8.1
- Nominal and measured concentrations:
- Nominal concentration used for FAT 36052/D dissolved with acetone and dissolved with Tween 80:
2 mg/l
20 mg/l
100 mg/l (Sediment)
200 mg/l
1000 mg/l - Details on test conditions:
- 8 trouts were used for the experiment where FAT 36052/D was dissolved with acetone and 8 trouts were used in the experiment where FAT 36052/D was dissolved with Tween 80.
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Details on results:
- - No mortality after 48h in the experiment where FAT 36052/D is dissolved with acetone (8/8 are alive)
- No mortality after 48h in the experiment where FAT 36052/D is dissolved with Tween 80 (8/8 are alive) - Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the result for FAT 36052/D dissolved in acetone and for FAT 36052/D dissolved in Tween 80 are:
*LC 0 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC 50 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC100 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80) - Executive summary:
The acute fish toxicity study experiment was done with 8 fishes for each experiment (first FAT 36052/D is dissolved with Tween 80 and in the second, FAT 36052/D is dissolved with acetone). The temperature was 14 °C for both experience. During the test, the pH was between 8 and 8.1. At concentration 100 mg/L, 200 mg/L and 1000 mg/L of FAT 36052/D all fishes were alive at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).
In conclusion:
*LC 0 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC 50 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
*LC100 >1000 mg/L: (FAT 36052/D dissolved in acetone and in Tween 80)
Reference
Description of key information
In all the three studies performed at concentration ranging from 3 mg/L to 1000 mg/L of FAT 36052/D there was no mortality noted at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
At Ciba Geigy AG acute fish toxicity testing was performed according to published methods, which were adapted and standardized for the specific needs of the company, well before Test Guidelines for these methods were established by the OECD beginning 1981. These methods were comparable to today’s standard testing procedure published by the OECD within Guideline for Testing of Chemicals 203: Fish, Acute Toxicity Test, adopted by the Council on 17thJuly 1992. In all the three studies performed at concentration ranging from 3 mg/L to 1000 mg/L of FAT 36052/D there was no mortality noted at 24 hours and 48 hours for both conditions (dissolved with Tween 80 and with acetone).
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