Isodecyl acrylate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1962

Report date:

1962

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Male albino rabbits were immobilized during the 24 -hour contact period with the compound.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isodecyl acrylate

EC Number:

215-542-5

EC Name:

Isodecyl acrylate

Cas Number:

1330-61-6

Molecular formula:

C13H24O2

IUPAC Name:

2-methyloctyl prop-2-enoate

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 3 - 5 months
- Weight at study initiation: 2.5 kg
- Diet (e.g. ad libitum): Rockland rabbit ration

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Male albino New Zealand strain rabbits, three to five months of age and averaging 2.5 kg. in weight were immobilized during the 24-hour skin contact
period. Thereafter, the polyethylene sheeting used to retain the dose in contact with the clipped skin of the trunk was removed and the animals were
caged for the remainder of the lU-day observation period. The rabbits were procured locally and maintained on Rockland rabbit ration. The moving average method of calculating the LD50 was used.

Duration of exposure:

24 h

Doses:

5, 1.5 and 1.25 ml/kg

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

3 140 mg/kg bw

Remarks on result:

other: Original data: 3.54 ml/kg

Mortality:

5 ml/kg: 2/4 animals died (on days 2 and 3 after exposure)
2,5 ml/kg: 2/4 animals died (on days 2 and 3 after exposure)
1,25 ml/kg: no animal died

Clinical signs:

other: no details available

Gross pathology:

Gross examination at autopsy revealed congested lungs and brownish, mottled livers and kidneys with surface markings prominent on both organs.

Other findings:

no

Any other information on results incl. tables

Single Doses to Male Albino Rabbits by Skin Penetration Administered Undiluted under Polyethylene Dam for 24 Hrs.

Rat Number	1962 Date Dosed	1962 Date Applied	Grams Weight	Weight Change  in 14 Days	Dosage; ml/kg	Dose in ml	Days to Death
54299	6-4	6-6	2318	-	5.0	11.6	2
54308	6-4	6-6	2300	-	5.0	11.5	3
54311	6-5	6-6	2384	-36	5.0	11.9	-
54313	6-5	6-6	2434	+180	5.0	12.2	-
54260	5-23	5-24	2628	-	2.5	6.6	3
54273	5-28	5-29	2250	-	2.5	5.6	2
54258	5-23	5-24	2472	+584	2.5	6.2	-
54274	5-28	5-29	2335	+279	2.5	5.8	-
52091	5-29	5-31	2314	+346	1.25	2.9	-
54240	5-29	5-31	2540	+350	1.25	3.2	-
54246	5-29	5-31	2134	+286	1.25	2.6	-
54290	5-29	5-31	2244	+251	1.25	2.2	-

LD50: 3.54 (1.17 to 10.7) ml/kg

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

According to these experimental conditions, the dermal LD50 is calculated to 3140 mg/kg bw in rabbits.

Executive summary:

In this study, rabbits were treated dermally with isodecyl acrylate a single dose of 1,25 - 2,5 or 5 ml/kg.

Two animals died at the doses of 2,5 and 5 ml/kg on days 2 and 3 after 14 days after administration. No animal died at the dose of 1,25 ml/kg.

A dermal LD50 value of approx. 3150 mg/kg bw was calculated.