Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to microorganisms
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test method according to OECD TG 301 C. No data on GLP. .
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 301 C(Ready Biodegradability: Modified MITI Test (I))
GLP compliance:
not specified
Analytical monitoring:
yes
Vehicle:
not specified
Test organisms (species):
activated sludge
Details on inoculum:
- Initial biomass concentration: 30 mg/L
Test type:
other: Readily biodegradability
Water media type:
freshwater
Limit test:
no
Total exposure duration:
28 d
Details on test conditions:
TEST SYSTEM
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): BOD and test item concentration by HPLC.

TEST CONCENTRATIONS
- Test concentrations: 100 mg/L.
Reference substance (positive control):
not specified
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: % biodegradability

The test item was determined not to be toxic in the biodegradability test although not been readily biodegradable.

Validity criteria fulfilled:
not specified
Conclusions:
The NOEC for microorganism toxicity of the test item was determined to be 100 mg/L.
Executive summary:

A readily biodegradation test was performed on 2 -methylcyclohexyl acetate by MITI according to OECD Guideline 301 C. 30 mg/L of activated sludge were exposed to 100 mg/L test item for 4 weeks. The biodegradation obtained by indirect analysis was 0 (basis for effect: BOD), and by direct analysis 2% (basis for effect: HPLC). The test item was deterined not to be toxic under test conditions. According to the current guidelines, the NOEC for microorganism toxicity was determined to be 100 mg/L.

Description of key information

Key study: OECD 301C. No data on GLP. The NOEC for microorganism toxicity was determined to be 100 mg/L.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:
100 mg/L

Additional information

Key study: Experimental results:

A readily biodegradation test was performed on test item by MITI according to OECD Guideline 301 C. The NOEC for microorganism toxicity was determined to be 100 mg/L.

Categories Display