Registration Dossier
Registration Dossier
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EC number: 202-764-2 | CAS number: 99-54-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Some study details are missing. However, method and results are sufficiently described.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The formation of mercapturic acids. 1. Formation of mercapturic acid and the levels of glutathione in tissues.
- Author:
- Barnes MM, James SP, Wood PB
- Year:
- 1 959
- Bibliographic source:
- Biochem J 71: 680 - 690
- Reference Type:
- review article or handbook
- Title:
- OECD-Screening Information DataSet (SIDS) for High Production Volume Chemicals: 1,2-Dichloro-4-nitrobenzene
- Author:
- UNEP (United Nations Environmental Program - Chemical Branch)
- Year:
- 2 005
- Bibliographic source:
- United Nations
Materials and methods
- Objective of study:
- excretion
- Principles of method if other than guideline:
- see 'Additional information on material and methods'
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichloro-4-nitrobenzene
- EC Number:
- 202-764-2
- EC Name:
- 1,2-dichloro-4-nitrobenzene
- Cas Number:
- 99-54-7
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,2-dichloro-4-nitrobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: 1,2-dichloro-4-nitrobenzene, no data on purity
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- migrated dataset
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Females: I. 1820 µmole/kg bw (ca. 350 mg/kg bw); II. 1300 or 1820 µmole/kg bw (ca. 250 or 350 mg/kg bw)
Results and discussion
Any other information on results incl. tables
RS-Freetext:
I. About 19 % (range 4 - 29 %) of the applied dose was excreted as mercapturic acid in urine within 24 hrs.
II. The maximum rate for excretion of mercapturic acid via urine 2 - 6 days after dosing with 1300 or 1820 µmole/kg bw was
given with 10 or 21 µmole/kg bw/h.
Applicant's summary and conclusion
- Executive summary:
1,2 -dichloro-4-nitrobenzene is excreted mainly via urine in the form of mercapturic acid derivate N-acetyl-S-(2 -chloro-4-nitrophenyl)-L-cysteine (UNEP 2005).
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