Piperazine adipate

Toxicity to aquatic algae and cyanobacteria

Description of key information

The effective concentration (EC50) for piperazine adipate for Pseudokirchneriella subcapitata at 72 hours is estimated to be 119.68 mg/L for effect on growth. Based on this value it can be concluded that piperazine adipate is not toxic to aquatic environment based the criteria given by CLP regulation.

Key value for chemical safety assessment

EC50 for freshwater algae:

119.68 mg/L

EC10 or NOEC for freshwater algae:

37.85 mg/L

Additional information

Summary of weight of evidence - Toxicity to aquatic algae and cyanobacteria

No of studies reviewed for Toxicity to aquatic algae and cyanobacteria from reliable sources having Klimish rating 2 and 4

The summary if the results are presented below

 

Sr. No	Endpoint name	Value	Units	Species	Source
1	EC50	119.68	mg/l	Pseudokirchneriella subcapitata	Prediction report
2	NOEC	37.85	mg/l	Pseudokirchneriella subcapitata	Prediction report
3	EC50	356.64	mg/l	green algae	ECOSAR
4	EC50	479.62	mg/l	Pseudokirchneriella subcapitata	DEPA

 

Based on the above values it can be seen that the lethal concentration (LC50) values varies between 119.68 to 479.62 mg/l. From above values it can be concluded that the piperazine adipate is not toxic to aquatic environment based on the classification criteria of CLP regulation.