Registration Dossier
Registration Dossier
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EC number: 205-569-0 | CAS number: 142-88-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 82957
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource)Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure, Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 100, 1982.
- Reference Type:
- review article or handbook
- Title:
- DPIM: HEP000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials)Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure Izmerov, N.F., et al., Moscow, USSR.: , Centre of International Projects, GKNT, 1982, 100.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : MO1955000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,100,1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS, ACToR and Sax.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Piperazine adipate
- EC Number:
- 205-569-0
- EC Name:
- Piperazine adipate
- Cas Number:
- 142-88-1
- Molecular formula:
- C6H10O4.C4H10N2
- IUPAC Name:
- piperazine adipate
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material : piperazine adipate
- Molecular formula : C6H10O4.C4H10N2
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 8 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Oral toxicity (LD50) for piperazine adipate was examined in Rodent - mouse at dose concentration of 8000 mg/kg of body weight.Details of toxic effects not reported other than lethal dose value.This value suggests that piperazine does not exhibit acute toxicity through the oral route.
- Executive summary:
Oral toxicity (LD50) for piperazine adipate was examined in Rodent - mouse at dose concentration of 8000 mg/kg of body weight.Details of toxic effects not reported other than lethal dose value. This value suggests that piperazine does not exhibit acute toxicity through the oral route.
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