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Acute toxicity towards plants was tested on Avena sativa (oat), Glycine max (soy bean) and Brassica napus (rape) according to OECD guideline 208. The test was conducted according to OECD 208 using Chlorhexidine digluconate as test substance. As Chlorhexidine base is the active component, the results can be converted to equivalents of CHD-Base. No effects on seedling emergence were observed at the highest concentrations tested (NOECs were always ≥563 mg CHD-Base/kg dry soil). Seedling growth, as determined by shoot fresh-weight and -height, was a more sensitive endpoint displaying EC50s between 296 and >563 mg CHD-Base/kg dry soil.

In a limit test according to OECD 207 Chlorhexidine digluconate was found to be not toxic to earthworms at 1000 mg Chlorhexidine digluconate/kg dw, corresponding to 563 mg Chlorhexidine base/kg dw.