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EC number: 202-715-5 | CAS number: 98-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1960
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The age of this study means it was not conducted according to OECD or GLP guidelines. However, the brief method outlined indicates it conformed to guidelines available at the time.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test susbtance was applied to the eyes of rabbits and observations were made after 1 and 24 hours and 8 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-dimethylcyclohexylamine
- Cas Number:
- 98-94-2
- IUPAC Name:
- N,N-dimethylcyclohexylamine
- Reference substance name:
- N,N-dimethylcyclohexanamine
- Cas Number:
- 98-94-2
- IUPAC Name:
- N,N-dimethylcyclohexanamine
- Reference substance name:
- Cyclohexyldimethylamine
- EC Number:
- 202-715-5
- EC Name:
- Cyclohexyldimethylamine
- Cas Number:
- 98-94-2
- Molecular formula:
- C8H17N
- IUPAC Name:
- N,N-dimethylcyclohexanamine
- Details on test material:
- - Name of test material (as cited in study report): Dimethylcyclohexylamin- Molecular formula (if other than submission substance): Not documented- Molecular weight (if other than submission substance): Not documented- Smiles notation (if other than submission substance): Not documented- InChl (if other than submission substance): Not documented- Structural formula attached as image file (if other than submission substance): see Fig. Not documented- Substance type: Not documented- Physical state: Liquid- Analytical purity: Not documented- Impurities (identity and concentrations): Not documented- Composition of test material, percentage of components: Not documented- Isomers composition: Not documented - Purity test date: Not documented- Lot/batch No.: Not documented- Expiration date of the lot/batch: Not documented- Radiochemical purity (if radiolabelling): Not documented- Specific activity (if radiolabelling): Not documented- Locations of the label (if radiolabelling): Not documented- Expiration date of radiochemical substance (if radiolabelling): Not documented- Stability under test conditions: Not documented- Storage condition of test material: Not documented- Other: Not documented
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No information provided
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 5 -20% Solution - Duration of treatment / exposure:
- 8 days
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- Not specified
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not documented
- Time after start of exposure: Not documented
SCORING SYSTEM: Not documented
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein Not documented
Results and discussion
In vivo
- Irritant / corrosive response data:
- Etching of the conjunctiva was observed at all time points examined, in addition to a milky opacity of the cornea. After 8 days, etching of the haw was observed, in addition to scarring and the corneal effects.
- Other effects:
- No other effects observed
Any other information on results incl. tables
No additional information provided.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Under the conditions of this experiment, the test substance should be considered to be corrosive. According to Regulation EC No. 1272/20008, the test substance should be classified as Eye Dam 1 and should have the hazard phrase H318: "Causes serious eye damage" and the signal word Danger associated with it. According to Directive 67/548/5EEC, the test substance should be classified as R41 Risk of serious damage to eyes and have the symbol Xi and Danger associated with it.
- Executive summary:
In a study conducted by BASF in 1960, the test substance, cyclohexyldimethylamine (DMCHA), was applied to the eyes of rabbits to determine its potential as an eye irritant. The test substance was applied undiluted as a 5 -20% solution. Following application, the eyes were observed after 1 and 24 hours and then again after 8 days. Etching of the conjunctiva was observed 1 and 24 hours with etching of the haw observed after 8 days. Effects were also observed on corneal opacity. Under the conditions of this experiment, the test substance should be considered to be corrosive. According to Regulation EC No. 1272/20008, the test substance should be classified as Eye Dam 1 and should have the hazard phrase H318: "Causes serious eye damage" and the signal word Danger associated with it. According to Directive 67/548/5EEC, the test substance should be classified as R41 Risk of serious damage to eyes and have the symbol Xi and Danger associated with it.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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