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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
Administration of a single oral dose of the test substance to Sprague-Dawley rats to determine the acute oral toxicity.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-propylheptan-1-ol
EC Number:
233-126-1
EC Name:
2-propylheptan-1-ol
Cas Number:
10042-59-8
Molecular formula:
C10H22O
IUPAC Name:
2-propylheptan-1-ol
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-Propylheptanol
- Lot/batch No.: NBP 1282594-A

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males: 235 - 250 g, females: 235-245 g;

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses:
5010, 6310, 7940, 10000 mg/kg
No. of animals per sex per dose:
5 animals per dose (males and females)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
5 400 mg/kg bw
Based on:
test mat.
95% CL:
>= 5 020 - <= 5 780
Mortality:
- 5010 mg/kg bw: males: 0/2, females: 1/3;
- 6310 mg/kg bw: males: 3/3, females: 2/2;
- 7940 mg/kg bw: males: 2/2, females: 3/3;
- 10000 mg/kg bw: males: 3/3, females: 2/2;

Deaths occurred between days 2 - 5
Clinical signs:
other: Increasing weakness, ocular discharge, diarrhea, collapse
Gross pathology:
Decedents: Hemorrhagic lungs, liver discoloration, and acute gastrointestinal inflammation;
Survivors: Viscera appeared normal;

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to the results of the study a LD 50 value of 5400 mg/kg bw was established under these test conditions. Therefore no classification according to EU or GHS criteria is required.