Registration Dossier
Registration Dossier
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EC number: 233-126-1 | CAS number: 10042-59-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Administration of a single oral dose of the test substance to Sprague-Dawley rats to determine the acute oral toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-propylheptan-1-ol
- EC Number:
- 233-126-1
- EC Name:
- 2-propylheptan-1-ol
- Cas Number:
- 10042-59-8
- Molecular formula:
- C10H22O
- IUPAC Name:
- 2-propylheptan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Propylheptanol
- Lot/batch No.: NBP 1282594-A
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 235 - 250 g, females: 235-245 g;
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5010, 6310, 7940, 10000 mg/kg
- No. of animals per sex per dose:
- 5 animals per dose (males and females)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 400 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 5 020 - <= 5 780
- Mortality:
- - 5010 mg/kg bw: males: 0/2, females: 1/3;
- 6310 mg/kg bw: males: 3/3, females: 2/2;
- 7940 mg/kg bw: males: 2/2, females: 3/3;
- 10000 mg/kg bw: males: 3/3, females: 2/2;
Deaths occurred between days 2 - 5 - Clinical signs:
- other: Increasing weakness, ocular discharge, diarrhea, collapse
- Gross pathology:
- Decedents: Hemorrhagic lungs, liver discoloration, and acute gastrointestinal inflammation;
Survivors: Viscera appeared normal;
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of the study a LD 50 value of 5400 mg/kg bw was established under these test conditions. Therefore no classification according to EU or GHS criteria is required.
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